Skp2 - S-phase kinase-associated protein 2 Gene

Also Known as p45; FWD1; FBXL1; 4930500A04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27401

Summary

Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including cellular protein metabolic process; mitotic cell cycle phase transition; and positive regulation of intracellular Estrogen receptor signaling pathway. Part of SCF ubiquitin Ligase complex. Is expressed in several structures, including blastocyst; compacted morula; and retina nuclear layer. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Skp2 Products (2)

mRNA Protein Name
NM_001285980.1 NP_001272909.1 S-phase kinase-associated protein 2 isoform c
NM_013787.3 NP_038815.1 S-phase kinase-associated protein 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
17785450 MGI
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
22464731 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
10790373 MGI
acts upstream of or within G2/M transition of mitotic cell cycle IGI
IGI: Inferred from genetic interaction
19056892 MGI
acts upstream of or within G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
19056892 MGI
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
22464731 MGI
acts upstream of or within positive regulation of intracellular estrogen receptor signaling pathway IGI
IGI: Inferred from genetic interaction
17785450 MGI
acts upstream of or within positive regulation of protein polyubiquitination IDA
IDA: Inferred from direct assay
23277542 MGI
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
22464731 MGI
acts upstream of or within protein polyubiquitination IDA
IDA: Inferred from direct assay
17785450 MGI
acts upstream of or within regulation of cell cycle IPI
IPI: Inferred from physical interaction
10790373 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
10790373 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
19056892 MGI
Cellular Component GO Annotation Evidence Références Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
17785450 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

S-phase kinase-associated protein 2

  • F-box protein Skp2

  • F-box/WD-40 protein 1

  • cyclin A/CDK2-associated protein p45

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-N0256 Hederagenin Ligand 99.95% Unkown
HY-153937 Skp2 inhibitor 2 Inhibitor 99.88% Unkown
HY-162938 Skp2 inhibitor 3 Inhibitor 98.07% Unkown
HY-181653 PROTAC SKP2 Degrader-1 Degrader 99.91% Unkown
HY-P11792 CP2-CPP / Unkown
HY-129108 9-cis-UAB30 Inhibitor / Unkown
HY-P11020 p27 Analogue CP2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Skp2 NCBI NCBI:6502