2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. Skp2 inhibitor 2

Skp2 inhibitor 2 is a Skp2-Cks1 protein-protein interaction inhibitor with a human IC50 of 0.57 μM. Skp2 inhibitor 2 binds to Skp2 at the interaction interface to block Skp2-Cks1 complex formation. Skp2 inhibitor 2 can be used for the research of gastric cancer, non-small cell lung cancer, breast cancer, prostate cancer.

For research use only. We do not sell to patients.

Skp2 inhibitor 2

Skp2 inhibitor 2 Chemical Structure

CAS No. : 2760612-77-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Skp2 inhibitor 2 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Skp2 inhibitor 2 is a Skp2-Cks1 protein-protein interaction inhibitor with a human IC50 of 0.57 μM. Skp2 inhibitor 2 binds to Skp2 at the interaction interface to block Skp2-Cks1 complex formation. Skp2 inhibitor 2 can be used for the research of gastric cancer, non-small cell lung cancer, breast cancer, prostate cancer[1].

IC50 & Target[1]

Skp2

0.57 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
51.8 μM
Compound: 14ag
Antitumor activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antitumor activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 37204466]
MGC-803 IC50
> 100 μM
Compound: 14ag
Antitumor activity against human MGC-803 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antitumor activity against human MGC-803 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 37204466]
NCI-H1299 IC50
59 μM
Compound: 14ag
Antitumor activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antitumor activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 37204466]
PC-3 IC50
68 μM
Compound: 14ag
Antitumor activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antitumor activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 37204466]
In Vitro

Skp2 inhibitor 2 (14ag) potently inhibits the Skp2-Cks1 protein-protein interaction in a cell-free HTRF assay with an IC50 of 0.57 μM[1].
Skp2 inhibitor 2 binds to the Skp2 protein via multiple hydrogen bonds and π-stacking interactions, occupying the Skp2-Cks1 binding site[1].
Skp2 inhibitor 2 (72 h) exhibits poor antiproliferative activity against Skp2-high-expressed MGC-803, NCI-H1299, MCF-7, EC-1, and PC-3 tumor cell lines, with IC50 values ranging from 51.8 μM to > 100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Skp2 inhibitor 2 Related Antibodies
Molecular Weight

428.57

Formula

C27H32N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C)(C)C)NCC1CCN(CC1)C2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 12 mg/mL (28.00 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3333 mL 11.6667 mL 23.3334 mL
5 mM 0.4667 mL 2.3333 mL 4.6667 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3333 mL 11.6667 mL 23.3334 mL 58.3335 mL
5 mM 0.4667 mL 2.3333 mL 4.6667 mL 11.6667 mL
10 mM 0.2333 mL 1.1667 mL 2.3333 mL 5.8334 mL
15 mM 0.1556 mL 0.7778 mL 1.5556 mL 3.8889 mL
20 mM 0.1167 mL 0.5833 mL 1.1667 mL 2.9167 mL
25 mM 0.0933 mL 0.4667 mL 0.9333 mL 2.3333 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Skp2 inhibitor 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Skp2 inhibitor 22760612-77-7E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseMGC-803breast cancerSkp2esophageal cancerprostate cancernon-small cell lung cancerCks1NCI-H1299Skp2-Cks1gastric cancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Skp2 inhibitor 2
Cat. No.:
HY-153937
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.