Skp2 inhibitor 2
Based on 1 Customer Validation
Skp2 inhibitor 2 is a Skp2-Cks1 protein-protein interaction inhibitor with a human IC50 of 0.57 μM. Skp2 inhibitor 2 binds to Skp2 at the interaction interface to block Skp2-Cks1 complex formation. Skp2 inhibitor 2 can be used for the research of gastric cancer, non-small cell lung cancer, breast cancer, prostate cancer.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 2760612-77-7
- Formula: C27H32N4O
- Molecular Weight:428.57
-
Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Skp2 0.57 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
51.8 μM
Compound: 14ag
|
Antitumor activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antitumor activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 37204466] |
| MGC-803 | IC50 |
>100 μM
Compound: 14ag
|
Antitumor activity against human MGC-803 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antitumor activity against human MGC-803 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 37204466] |
| NCI-H1299 | IC50 |
59 μM
Compound: 14ag
|
Antitumor activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antitumor activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 37204466] |
| PC-3 | IC50 |
68 μM
Compound: 14ag
|
Antitumor activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antitumor activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 37204466] |
Skp2 inhibitor 2 (14ag) potently inhibits the Skp2-Cks1 protein-protein interaction in a cell-free HTRF assay with an IC50 of 0.57 μM[1].
Skp2 inhibitor 2 binds to the Skp2 protein via multiple hydrogen bonds and π-stacking interactions, occupying the Skp2-Cks1 binding site[1].
Skp2 inhibitor 2 (72 h) exhibits poor antiproliferative activity against Skp2-high-expressed MGC-803, NCI-H1299, MCF-7, EC-1, and PC-3 tumor cell lines, with IC50 values ranging from 51.8 μM to > 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2760612-77-7
-
Appearance Solid
-
Molecular Weight 428.57
-
Formula C27H32N4O
-
Color White to off-white
-
SMILES
O=C(C(C)(C)C)NCC1CCN(CC1)C2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 12 mg/mL (28.00 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3333 mL | 11.6667 mL | 23.3334 mL | 58.3335 mL |
| 5 mM | 0.4667 mL | 2.3333 mL | 4.6667 mL | 11.6667 mL | |
| 10 mM | 0.2333 mL | 1.1667 mL | 2.3333 mL | 5.8334 mL | |
| 15 mM | 0.1556 mL | 0.7778 mL | 1.5556 mL | 3.8889 mL | |
| 20 mM | 0.1167 mL | 0.5833 mL | 1.1667 mL | 2.9167 mL | |
| 25 mM | 0.0933 mL | 0.4667 mL | 0.9333 mL | 2.3333 mL |
Skp2 inhibitor 2 Related Classifications
HY-153937 Related Classifications
Powered by Bioz