SKP2 - S-phase kinase associated protein 2 Gene

Also Known as p45; FBL1; FLB1; FBXL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6502

About SKP2

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:36,152,111-36,193,530 (from NCBI)

This gene has 26 transcripts (splice variants), 256 orthologues and 15 paralogues. Broad expression in placenta (RPKM 19.8), lymph node (RPKM 3.9) and 22 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]

SKP2 Products (3)

mRNA	Protein	Name
NM_001243120.2	NP_001230049.1	S-phase kinase-associated protein 2 isoform 3
NM_005983.4	NP_005974.2	S-phase kinase-associated protein 2 isoform 1
NM_032637.4	NP_116026.1	S-phase kinase-associated protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22770219	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11099048	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	22464731	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	27194766	GOA
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	27194766	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	22464731	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	27194766	GOA
involved in protein K48-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	27194766	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	22464731	GOA
acts upstream of or within regulation of apoptotic process	IDA IDA: Inferred from direct assay	23277542	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16880511	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SKP2 Protein Structure

F-box-like

0
100
200
300
400
424 a.a.

Protein Preferred Names	Protein Names
S-phase kinase-associated protein 2	CDK2/cyclin A-associated protein p45

SKP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SKP2	Q13309	SKP1	Homo sapiens	P63208	CoIP	12609982
Intra	SKP2	Q13309	SKP1	Homo sapiens	P63208	Anti Tag CoIP	22632967
Intra	SKP2	Q13309	SKP1	Homo sapiens	P63208	Pull Down	18818696
Intra	SKP2	Q13309	SKP1	Homo sapiens	P63208	Pull Down	23911321
Intra	SKP2	Q13309	SKP1	Homo sapiens	P63208	Lumier	37398436
Intra	SKP2	Q13309	SKP1	Homo sapiens	P63208	Anti Tag CoIP	18239684
Intra	SKP2	Q13309	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	18239684
Intra	SKP2	Q13309	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	28514442
Intra	SKP2	Q13309	CUL1	Homo sapiens	Q13616	CoIP	12609982
Intra	SKP2	Q13309	CUL1	Homo sapiens	Q13616	Anti Bait CoIP	12504026
Intra	SKP2	Q13309	ORC1	Homo sapiens	Q13415	CoIP	11931757
Intra	SKP2	Q13309	CDKN1A	Homo sapiens	P38936	PLA	25241761
Intra	SKP2	Q13309	RBX1	Homo sapiens	P62877	Anti Tag CoIP	18239684
Intra	SKP2	Q13309	EP300	Homo sapiens	Q09472	Anti Bait CoIP	22770219
Intra	SKP2	Q13309	MYC	Homo sapiens	P01106	Anti Bait CoIP	17157259
Intra	SKP2	Q13309	CKS1B	Homo sapiens	P61024	CoIP	12813041
Intra	SKP2	Q13309	CKS1B	Homo sapiens	P61024	Anti Tag CoIP	18239684
Intra	SKP2	Q13309	CKS1B	Homo sapiens	P61024	Pull Down	12813041
Intra	SKP2	Q13309	SIRT3	Homo sapiens	Q9NTG7	Anti Bait CoIP	22770219
Intra	SKP2	Q13309	SIRT3	Homo sapiens	Q9NTG7	Deacetylase Assay	22770219
Intra	SKP2	Q13309	SIRT3	Homo sapiens	Q9NTG7	Anti Tag CoIP	22770219
Intra	SKP2	Q13309	FZR1	Homo sapiens	Q9UM11	Pull Down	22770219
Intra	SKP2	Q13309	CDH1	Homo sapiens	A5D8W4	Anti Tag CoIP	18239684
Intra	SKP2	Q13309	DUSP1	Homo sapiens	P28562	Enzymatic Study	16286470
Cross	SKP2	Q13309	Cdh1	Mus musculus	P09803	Anti Tag CoIP	22770219
Cross	SKP2	Q13309	Cdh1	Mus musculus	P09803	Pull Down	22770219
Cross	SKP2	Q13309	X	Hepatitis B virus	Q4AE16	Anti Bait CoIP	16376880
Cross	SKP2	Q13309	X	Hepatitis B virus	Q4AE16	Anti Tag CoIP	16376880

Cross: Cross-species interaction Intra: Intraspecies interaction

SKP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81587	SKP2 Antibody (YA1332)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P85367	SKP2 Antibody (YA5059)	WB, IHC-P	Mouse, Rat

Related Diseases

Diseases	Alias
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Cervical Squamous Cell Carcinoma	Squamous Cell Carcinoma Of The Cervix Uteri Squamous Cell Carcinoma Of Cervix
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Pancreatic Intraductal Papillary-Mucinous Adenoma
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0256	Hederagenin	Ligand	99.95%	Unkown
HY-153937	Skp2 inhibitor 2	Inhibitor	99.88%	Unkown
HY-162938	Skp2 inhibitor 3	Inhibitor	98.07%	Unkown
HY-181653	PROTAC SKP2 Degrader-1	Degrader	99.91%	Unkown
HY-P11792	CP2-CPP		/	Unkown
HY-129108	9-cis-UAB30	Inhibitor	/	Unkown
HY-P11020	p27 Analogue CP2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SKP2	VGNC	VGNC:65173
Mus musculus	SKP2	MGD	MGI:1351663
Macaca mulatta	SKP2	VGNC	VGNC:77376
Canis familiaris	SKP2	VGNC	VGNC:51910
Rattus norvegicus	SKP2	RGD	RGD:1562456
Others	SKP2	NCBI