SIRT3 - sirtuin 3 Gene

Also Known as SIR2L3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23410

About SIRT3

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:215,030-236,931 (from NCBI)

This gene has 16 transcripts (splice variants), 198 orthologues and 6 paralogues. Ubiquitous expression in testis (RPKM 6.7), brain (RPKM 5.6) and 25 other tissues.

Summary

SIRT3 encodes a member of the Sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate Reactive Oxygen Species, inhibit Apoptosis, and prevent the formation of Cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, Cancer, Cardiovascular Disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]

SIRT3 Products (38)

mRNA	Protein	Name
NR_163402.1
NM_001370316.1	NP_001357245.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform g precursor
NR_163388.1
NR_163400.1
NR_163395.1
NM_001370317.1	NP_001357246.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform h
NR_163386.1
XM_011519957.3	XP_011518259.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1
NR_163387.1
NR_163392.1
NR_163396.1
NR_163391.1
NM_001370310.1	NP_001357239.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform c
NR_163390.1
NR_163394.1
NM_001017524.3	NP_001017524.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b
NR_163398.1
NM_001370325.1	NP_001357254.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform j
XR_007062467.1
NM_001370312.1	NP_001357241.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform d
NM_001370319.1	NP_001357248.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b
XM_017017431.2	XP_016872920.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1
NM_001370320.1	NP_001357249.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b
NR_163401.1
NR_163393.1
NR_163399.1
NM_001370318.1	NP_001357247.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b
NM_001370324.1	NP_001357253.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform j
XM_011519956.3	XP_011518258.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1
NM_001370323.1	NP_001357252.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i
NR_163397.1
NM_012239.6	NP_036371.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform a
NM_001370322.1	NP_001357251.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i
NM_001370321.1	NP_001357250.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i
NR_163389.1
NM_001370314.1	NP_001357243.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform e
NM_001370315.1	NP_001357244.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform f precursor
XM_047426677.1	XP_047282633.1	NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16788062	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	29445193	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	19535340	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in aerobic respiration	IMP IMP: Inferred from mutant phenotype	22309213	GOA
involved in peptidyl-lysine deacetylation	IMP IMP: Inferred from mutant phenotype	22309213	GOA
involved in positive regulation of catalase activity	IDA IDA: Inferred from direct assay	25210848	GOA
involved in positive regulation of superoxide dismutase activity	IDA IDA: Inferred from direct assay	25210848	GOA
involved in protein deacetylation	IDA IDA: Inferred from direct assay	16788062	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	12186850	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	16079181	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23283301	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRT3 Protein Structure

SIR2

0
100
200
300
399 a.a.

Protein Preferred Names	Protein Names
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	NAD-dependent deacetylase sirtuin-3, mitochondrial SIR2-like protein 3 mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase regulatory protein SIR2 homolog 3 silent mating type information regulation 2, S.cerevisiae, homolog 3 sir2-like 3 sirtuin type 3

SIRT3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SIRT3	Q9NTG7	OPA1	Homo sapiens	O60313	Anti Tag CoIP	24344202
Intra	SIRT3	Q9NTG7	OPA1	Homo sapiens	O60313	Pull Down	24344202
Intra	SIRT3	Q9NTG7	ATP5F1A	Homo sapiens	P25705	Pull Down	19343720
Intra	SIRT3	Q9NTG7	ATP5F1A	Homo sapiens	P25705	Anti Tag CoIP	19343720

Cross: Cross-species interaction Intra: Intraspecies interaction

SIRT3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80892	SIRT3 Antibody (YA080)	WB, IHC-P	Human
HY-P80892A	SIRT3 Antibody (YA080)(PBS only)	WB, IHC-P	Human
HY-P84827	SIRT3 Antibody (YA4524)	WB, FC, ELISA	Human
HY-P84827A	SIRT3 Antibody (YA4524)(PBS only)	WB, FC, ELISA	Human
HY-P86513	SIRT3 Antibody (YA6205)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Monckeberg Arteriosclerosis	Monckeberg Medial Calcific Sclerosis
Diabetes Mellitus	Diabetes
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Aging
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0130	Perindopril		99.85%	Yes
HY-B0130A	Perindopril erbumine		99.98%	Yes

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-123033A	Nicotinamide riboside chloride	Activator	99.90%	Phase 4
HY-123033C	Nicotinamide riboside malate	Activator	98.04%	Phase 4
HY-123033B	Nicotinamide riboside tartrate	Activator	98.07%	Phase 4
HY-123033	Nicotinamide riboside	Activator	/	Phase 4

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108331	3-TYP	Inhibitor	99.90%	Unkown
HY-113402	Gamma-glutamylcysteine	Activator	98.53%	Unkown
HY-100578	AGK2	Inhibitor	99.43%	Unkown
HY-158426	2-APQC	Agonist	99.70%	Unkown
HY-15510	Tenovin-6	Inhibitor	98.00%	Unkown
HY-N1511	Ganoderic acid D	Activator	99.89%	Unkown
HY-N2110	Phellopterin	Agonist	99.94%	Unkown
HY-119575	Tetramethyluric acid	Activator	99.63%	Unkown
HY-16616	SIRT-IN-2	Inhibitor	98.08%	Unkown
HY-136199	SIRT1-IN-1	Inhibitor	98.15%	Unkown
HY-N2673	5-Heptadecylresorcinol	Activator	99.83%	Unkown
HY-16605	SIRT6-IN-6	Inhibitor	98.59%	Unkown
HY-163987	SIRT3 activator 2	Activator	98.94%	Unkown
HY-15510B	Tenovin-6 Hydrochloride	Inhibitor	98.88%	Unkown
HY-173572	SKLB-11A	Agonist	99.40%	Unkown
HY-161920	SIRT3-IN-1	Inhibitor	98.47%	Unkown
HY-124113	4'-Bromo-resveratrol	Inhibitor	99.94%	Unkown
HY-16615	SIRT-IN-1	Inhibitor	98.14%	Unkown
HY-111329	JGB1741	Inhibitor	99.37%	Unkown
HY-19339	Tenovin-3	Degrader	98.0%	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	98.37%	Unkown
HY-136855	MitoPBN	Modulator	95.00%	Unkown
HY-P3364A	Ac-QPKK(Ac)-AMC acetate	Substrate	99.38%	Unkown
HY-151519	SIRT2-IN-9	Inhibitor	99.45%	Unkown
HY-118343	AC-93253	Inhibitor	99.3%	Unkown
HY-111303	CHIC35	Inhibitor	/	Unkown
HY-155784	SPC-180002	Inhibitor	/	Unkown
HY-170402	SIRT6-IN-4	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-146013	Sirt1/2-IN-1	Inhibitor	/	Unkown
HY-114906	SIRT1/2/3-IN-2	Inhibitor	/	Unkown
HY-160944	hsa62	Inhibitor	/	Unkown
HY-160617	SIRT2-IN-14	Inhibitor	/	Unkown
HY-184173	OXPHOS-IN-3	Inhibitor	/	Unkown
HY-118109	SIRT3-IN-2	Inhibitor	/	Unkown
HY-W109401	SIRT-IN-6	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SIRT3	VGNC	VGNC:46184
Felis catus	SIRT3	VGNC	VGNC:65157
Rattus norvegicus	SIRT3	RGD	RGD:1308374
Bos taurus	SIRT3	VGNC	VGNC:34632
Macaca mulatta	SIRT3	VGNC	VGNC:77234
Mus musculus	SIRT3	MGD	MGI:1927665
Others	SIRT3	NCBI