SIAH3 - siah E3 ubiquitin protein ligase family member 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 283514

About SIAH3

Cytogenetic location: 13q14.13 Genomic coordinates (GRCh38): 13:45,777,242-45,851,753 (from NCBI)

This gene has 1 transcript (splice variant), 111 orthologues and 3 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein Ligase activity. Involved in negative regulation of protein targeting to mitochondrion and regulation of protein stability. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SIAH3 Products (1)

mRNA Protein Name
NM_198849.3 NP_942146.2 seven in absentia homolog 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein targeting to mitochondrion IDA
IDA: Inferred from direct assay
24270810 GOA
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
24270810 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
24270810 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIAH3 Protein Structure

Sina

Sina: Seven in absentia protein family (90 - 254)

  • 0
  • 100
  • 200
  • 269 a.a.
Protein Preferred Names Protein Names

seven in absentia homolog 3

  • siah-3

SIAH3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SIAH3 Q8IW03 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
SIAH3 Q8IW03 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12893 SIAH3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SIAH3 VGNC VGNC:97628
Mus musculus SIAH3 MGD MGI:2685758
Bos taurus SIAH3 VGNC VGNC:106928
Rattus norvegicus SIAH3 RGD RGD:1592168
Macaca mulatta SIAH3 VGNC VGNC:106295
Canis familiaris SIAH3 VGNC VGNC:46164
Others SIAH3 NCBI