Nit1 - nitrilase 1 Gene

The protein encoded by this gene is a member of the nitrilase enzyme superfamily. Nitrilases are nonpeptidic C-N hydrolases. In mammals, nitrilases form small molecule C-N bonds such as acid amides, carbamates and ureas. Nit1-deficient mice display phenotypes including increased cell proliferation, resistance to DNA damage, and an increased number of N-nitrosomethylbenzylamine-induced murine forestomach tumors, suggesting a tumor suppressor function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]