Cav3 - caveolin 3 Gene

Rattus norvegicus

Gene ID: 29161 | Gene type: protein coding

About Cav3

Summary

Enables several functions, including nitric-oxide synthase binding activity; Potassium Channel Inhibitor activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; positive regulation of cellular component organization; and response to ischemia. Located in several cellular components, including T-tubule; cell surface; and neuromuscular junction. Part of protein-containing complex. Colocalizes with several cellular components, including Z disc; intercalated disc; and sarcolemma. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); isolated elevated serum creatine phosphokinase levels; and muscle tissue disease (multiple). Orthologous to human CAV3 (caveolin 3). [provided by Alliance of Genome Resources, Apr 2022]

Cav3 Products(1)

mRNA	Protein	Name
NM_019155.2	NP_062028.1	caveolin-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	16479074	RGD
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	15961389	RGD
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	15007069	RGD
enables potassium channel inhibitor activity	IMP IMP: Inferred from mutant phenotype	22879586	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12649076	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	22879586	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell differentiation	IEP IEP: Inferred from expression pattern	16135403	RGD
involved in cellular response to ionomycin	IEP IEP: Inferred from expression pattern	15725944	RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	21170593	RGD
involved in negative regulation of potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	22879586	RGD
involved in negative regulation of potassium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	22879586	RGD
involved in positive regulation of caveolin-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	22879586	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21508095	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	16318846	RGD
involved in positive regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	16480946	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	29438664	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	29438664	RGD
involved in ventricular cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	22879586	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	9925767	RGD
located in Z disc	IDA IDA: Inferred from direct assay	15980179	RGD
located in caveola	IDA IDA: Inferred from direct assay	9925767	RGD
located in cell surface	IDA IDA: Inferred from direct assay	12649076	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	15961389	RGD
located in neuromuscular junction	IDA IDA: Inferred from direct assay	12923236	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	9925767	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	12649076	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	15961389	RGD
located in vesicle	IDA IDA: Inferred from direct assay	11884374	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

caveolin-3

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-B0166	L-Ascorbic acid	99.97%	Unkown
HY-B0166A	L-Ascorbic acid sodium salt	99.97%	Unkown
HY-B0166R	L-Ascorbic acid (Standard)	99.97%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-B0166GL	L-Ascorbic acid (GMP Like)		99.88%	Phase 4
HY-B0166G	L-Ascorbic acid (GMP)		/	Phase 2
HY-115681	(2R/S)-6-PNG	Inhibitor	99.96%	Phase 1

Pre-clinical Phase

Bioactive Molecules (39)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111828	TTA-A2	Antagonist	99.33%	Unkown
HY-W011235	Norfluoxetine hydrochloride	Inhibitor	99.58%	Unkown
HY-103309	ML218	Inhibitor	99.49%	Unkown
HY-132184	5,6-Epoxyeicosatrienoic acid	Inhibitor	99.9%	Unkown
HY-B0166S	L-Ascorbic acid-13C6		99.90%	Unkown
HY-120597	SAK3	Activator	99.80%	Unkown
HY-B0166S6	L-Ascorbic acid-d2		99.90%	Unkown
HY-B0166S1	L-Ascorbic acid-13C		99.90%	Unkown
HY-P1441A	Mambalgin 1 TFA	Inhibitor	95.72%	Unkown
HY-B0166S8	L-Ascorbic acid-13C6-1		99.37%	Unkown
HY-112499S1	Menaquinone-7-13C6		96.0%	Unkown
HY-147638	MONIRO-1	Inhibitor	99.18%	Unkown
HY-50707	(Rac)-TTA-P2	Control	98.69%	Unkown
HY-B0166S3	L-Ascorbic acid-13C-2		95.0%	Unkown
HY-103309A	ML218 hydrochloride	Inhibitor	/	Unkown
HY-10035A	(R)-TTA-P2	Control	99.95%	Unkown
HY-103309S	ML218-d9	Inhibitor	/	Unkown
HY-118030	RQ-00311651	Antagonist	/	Unkown
HY-126336	HM12	Inhibitor	/	Unkown
HY-129841	Niguldipine monohydrochloride	Inhibitor	/	Unkown
HY-132184S	5,6-Epoxyeicosatrienoic acid-d11		/	Unkown
HY-147639	Cav 2.2/3.2 blocker 1	Inhibitor	/	Unkown
HY-147708	T-Type calcium channel inhibitor 2	Inhibitor	/	Unkown
HY-151450	Cav 3.2 inhibitor 1	Inhibitor	/	Unkown
HY-151451	Cav 3.2 inhibitor 2	Inhibitor	/	Unkown
HY-151452	Cav 3.2 inhibitor 3	Inhibitor	/	Unkown
HY-154832	Cav 3.2 inhibitor 4	Inhibitor	/	Unkown
HY-177955	α-Obscurine derivative-1	Inhibitor	/	Unkown
HY-B0166E	L-Ascorbic acid magnesium		/	Unkown
HY-B0166S2	L-Ascorbic acid-13C-1		99.90%	Unkown
HY-B0166S4	L-Ascorbic acid-13C-3		/	Unkown
HY-B0166S5	L-Ascorbic acid-13C-4		/	Unkown
HY-P5793	GTx1-15	Inhibitor	/	Unkown
HY-P5869	Kurtoxin		/	Unkown
HY-RS01988	CAV3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-112499S	Menaquinone-7-d7		/	Unkown
HY-122201	NSC156529	Antagonist	/	Unkown
HY-156889	Cav 3.1 blocker 1	Antagonist	/	Unkown
HY-P3269	Calciseptine	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cav3	NCBI	NCBI:859

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