GRPR - gastrin releasing peptide receptor Gene

Also Known as BB2; BB2R; BRS2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2925

About GRPR

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:16,123,565-16,153,518 (from NCBI)

This gene has 1 transcript (splice variant), 254 orthologues and 15 paralogues. Biased expression in pancreas (RPKM 2.4), stomach (RPKM 0.7) and 3 other tissues.

Summary

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal Hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the Phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]

GRPR Products (1)

mRNA Protein Name
NM_005314.3 NP_005305.1 gastrin-releasing peptide receptor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled peptide receptor activity IDA
IDA: Inferred from direct assay
1655761 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
1655761 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRPR Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (57 - 320)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
Protein Preferred Names Protein Names

gastrin-releasing peptide receptor

  • GRP-R

Related Diseases

Diseases Alias
Agoraphobia

  • Fear Of Open Spaces

  • Phobia Of Going Out
Gastrinoma

  • Gastrin Cell Tumour

  • Gastrin Secreting Tumor

  • Malignant Gastrinoma

  • Gastrinoma, Malignant
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Neuroendocrine Tumor

  • Neuroendocrine Neoplasm

  • Neuroendocrine Tumors

  • Carcinoma, Neuroendocrine
Castration-Resistant Prostate Carcinoma

  • Prostatic Neoplasms, Castration-Resistant
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Small Cell Cancer Of The Lung

  • Small Cell Lung Cancer

  • Small Cell Lung Carcinoma

  • Sclc

  • Small-Cell Cancer Of Lung

  • Lung Small Cell Carcinoma

  • Sclc1

  • Sccl

  • Cancer, Lung, Small Cell

  • Small Cell Carcinoma Of Lung

  • Carcinoma, Small Cell
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. 상품명 효과
Purity Phase
HY-P0107 RC-3095 Antagonist 99.43% Phase 2
HY-P0039 BIM-26226 Antagonist 98.73% Phase 1

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-116216 PD 168368 Antagonist ≥99.0% Unkown
HY-P0107A RC-3095 TFA Antagonist 99.66% Unkown
HY-W782083 p-SCN-Bn-NOTA trihydrochloride 99.75% Unkown
HY-N2909 Aurantiamide Inhibitor 99.56% Unkown
HY-P1423A BA 1 TFA Agonist 99.35% Unkown
HY-N2600 Kuwanon H 98.60% Unkown
HY-W343750 [Tyr4]-Bombesin Agonist 98.66% Unkown
HY-P10896 NOTA-P2-RM26 97.20% Unkown
HY-P5413 [Lys3]-Bombesin 99.39% Unkown
HY-115974 GRPR antagonist-1 99.80% Unkown
HY-115975 GRPR antagonist-2 Antagonist / Unkown
HY-176150 AMTG-DA1 Ligand / Unkown
HY-N2600R Kuwanon H (Standard) / Unkown
HY-P11352 JMV594 Antagonist / Unkown
HY-P11768 AMBA Ligand / Unkown
HY-P11769 RM2 Antagonist / Unkown
HY-P1423 BA 1 Agonist / Unkown
HY-P5520 GB-6 Chemical / Unkown
HY-RS05847 GRPR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-168633 PSMA/GRPR ligand 1 / Unkown
HY-180434 GRPR antagonist-3 Antagonist / Unkown
HY-RS17163 Grpr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23613 Grpr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GRPR VGNC VGNC:41519
Felis catus GRPR VGNC VGNC:67484
Rattus norvegicus GRPR RGD RGD:2750
Macaca mulatta GRPR VGNC VGNC:73295
Bos taurus GRPR VGNC VGNC:29666
Mus musculus GRPR MGD MGI:95836
Others GRPR NCBI