Rnf4 - ring finger protein 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29274

Summary

Enables several functions, including SUMO polymer binding activity; TBP-class protein binding activity; and nuclear receptor binding activity. Involved in several processes, including cellular response to gamma radiation; cellular response to hydroxyurea; and protein ubiquitination. Located in cytosol and nucleoplasm. Colocalizes with PML body. Orthologous to human RNF4 (ring finger protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Rnf4 Products (1)

mRNA Protein Name
NM_019182.2 NP_062055.1 E3 ubiquitin-protein ligase RNF4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11319220 RGD
enables SUMO polymer binding IDA
IDA: Inferred from direct assay
18408734 RGD
enables SUMO polymer binding IPI
IPI: Inferred from physical interaction
18408734 RGD
enables TBP-class protein binding IDA
IDA: Inferred from direct assay
9710597 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
21857666 RGD
enables nuclear androgen receptor binding IPI
IPI: Inferred from physical interaction
9710597 RGD
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
9710597 RGD
enables nucleosome binding IDA
IDA: Inferred from direct assay
11319220 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20696907 RGD
enables ubiquitin conjugating enzyme binding IPI
IPI: Inferred from physical interaction
21857666 RGD
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
21857666 RGD
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
18408734 RGD
enables ubiquitin-protein transferase activity IMP
IMP: Inferred from mutant phenotype
14987998 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
21857666 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
20943951 RGD
involved in cellular response to cytokine stimulus IEP
IEP: Inferred from expression pattern
11292317 RGD
involved in cellular response to gamma radiation IMP
IMP: Inferred from mutant phenotype
22661230 RGD
involved in cellular response to hydroxyurea IMP
IMP: Inferred from mutant phenotype
22661230 RGD
involved in cellular response to testosterone stimulus IDA
IDA: Inferred from direct assay
9710597 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
12351196 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11319220 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9710597 RGD
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
18408734 RGD
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
18408734 RGD
involved in protein K6-linked ubiquitination IDA
IDA: Inferred from direct assay
18408734 RGD
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
18408734 RGD
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
21857666 RGD
involved in protein autoubiquitination IMP
IMP: Inferred from mutant phenotype
14987998 RGD
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
14987998 RGD
involved in response to arsenic-containing substance IDA
IDA: Inferred from direct assay
20943951 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
14749358 RGD
involved in response to human chorionic gonadotropin IEP
IEP: Inferred from expression pattern
14749358 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
12351196 RGD
Cellular Component GO Annotation Evidence References Source
located in PML body IDA
IDA: Inferred from direct assay
20943951 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
20943951 RGD
located in nucleus IDA
IDA: Inferred from direct assay
11319220 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF4

  • E3 ubiquitin ligase RNF4

  • RING-type E3 ubiquitin transferase RNF4

  • SNURF

  • small nuclear ring finger protein

Rnf4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Rnf4 O88846 APEX1 Homo sapiens P27695
Anti Tag CoIP
20696907
Intra
Rnf4 O88846 TDG Homo sapiens Q13569
Anti Tag CoIP
20696907
Intra
Rnf4 O88846 SUMO2 Homo sapiens P61956
Pull Down
21252943
Intra
Rnf4 O88846 PARP1 Homo sapiens P09874
Anti Bait CoIP
19779455
Intra
Rnf4 O88846 TRIM28 Homo sapiens Q13263
Pull Down
21252943
Intra
Rnf4 O88846 Rnf4 Rattus norvegicus O88846
FRET
21857666
Intra
Rnf4 O88846 Rnf4 Rattus norvegicus O88846
Solution Sedimentation
21857666
Intra
Rnf4 O88846 SUMO3 Homo sapiens P55854
Pull Down
21857666
Intra
Rnf4 O88846 Rnf4 Rattus norvegicus O88846
X-Ray Diffraction
21857666
Intra
Rnf4 O88846 Rnf4 Rattus norvegicus O88846
GMS
21857666
Intra
Rnf4 O88846 ubiq_human Homo sapiens DIP-24261N
Pull Down
21857666
Cross
Rnf4 O88846 UBE2D1 Homo sapiens P51668
Pull Down
21857666
Intra
Rnf4 O88846 UHRF1 Homo sapiens Q96T88
Pull Down
21252943
Intra
Rnf4 O88846 RPS27A Bos taurus P62990
Pull Down
21857666
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-143346 CCW16 98.73% Unkown
HY-184506 R4VPL3-1 / Unkown
HY-184508 E3 ligase Ligand 81 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnf4 NCBI NCBI:6047