Sigmar1 - sigma non-opioid intracellular receptor 1 Gene

Also Known as Oprs1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29336

About Sigmar1

Primary_assembly 5: 56,904,159-56,907,017 reverse strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 206 orthologues and is associated with 14 phenotypes. Biased expression in Liver (RPKM 836.2), Kidney (RPKM 18.1) and 9 other tissues.

Summary

Enables G protein-coupled Opioid Receptor activity. Involved in nervous system development. Predicted to be located in membrane; nuclear envelope; and postsynaptic density. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 16 and distal spinal muscular atrophy 2. Orthologous to human SIGMAR1 (sigma non-opioid intracellular receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sigmar1 Products (1)

mRNA Protein Name
NM_030996.2 NP_112258.2 sigma non-opioid intracellular receptor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled opioid receptor activity IDA
IDA: Inferred from direct assay
12438547 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17981125 RGD
Biological Process GO Annotation Evidence References Source
involved in nervous system development IDA
IDA: Inferred from direct assay
12438547 RGD
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
20018732 RGD
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
20018732 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20018732 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20018732 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sigmar1 Protein Structure

ERG2_Sigma1R

ERG2_Sigma1R: pfam04622 (25 - 213)

  • 0
  • 100
  • 200
  • 223 a.a.
Protein Preferred Names Protein Names

sigma non-opioid intracellular receptor 1

  • opioid receptor, sigma 1

  • sigma 1-type opioid receptor

  • sigma1-receptor

  • sigma1R

Sigmar1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Sigmar1 Q9R0C9 Kcna2 Mus musculus P63141
Anti Bait CoIP
23332758
Intra
Sigmar1 Q9R0C9 Hspa5 Rattus norvegicus P06761
Pull Down
17981125
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0837 Veratramine 99.88% Unkown
HY-RS12909 Sigmar1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS12910 Sigmar1 Rat Pre-designed siRNA Set A / Unkown
HY-RS12908 SIGMAR1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sigmar1 NCBI NCBI:10280