2. Gene
  3. Hspa5 - heat shock protein family A (Hsp70) member 5 Gene

Hspa5 - heat shock protein family A (Hsp70) member 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as BIP; GRP78; GRP 78

Gene ID: 25617 | Gene type: protein coding

About Hspa5

Primary_assembly 3: 18,055,405-18,059,891 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 257 orthologues, 13 paralogues and is associated with 37 phenotypes. Biased expression in Liver (RPKM 2693.8), Heart (RPKM 215.3) and 9 other tissues.

Summary

Enables misfolded protein binding activity and unfolded protein binding activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and cellular response to metal ion. Acts upstream of or within response to endoplasmic reticulum stress. Located in membrane; mitochondrion; and smooth endoplasmic reticulum. Biomarker of fatty liver disease; post-traumatic stress disorder; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (HSP70) member 5). [provided by Alliance of Genome Resources, Apr 2022]

Hspa5 Products(1)

mRNA Protein Name
NM_013083.2 NP_037215.1 endoplasmic reticulum chaperone BiP precursor

Hspa5 Protein Structure

HSP70

HSP70: pfam00012 (29 - 634)

  • 0
  • 200
  • 400
  • 600
  • 654 a.a.
Protein Preferred Names Protein Names

endoplasmic reticulum chaperone BiP

78 kDa glucose-regulated protein

GRP-78

HSP70 family protein 5

binding-immunoglobulin protein

heat shock 70 kDa protein 5

heat shock 70kD protein 5

heat shock 70kDa protein 5 (glucose-regulated protein)

heat shock protein 5

heat shock protein 70 family protein 5

heat shock protein family A member 5

immunoglobulin heavy chain-binding protein

steroidogenesis-activator polypeptide

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125974 HM03 Inhibitor 99.34% Unkown
HY-152153 GRP78-IN-3 Inhibitor 99.98% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspa5 NCBI NCBI:3309
Mus musculus Hspa5 NCBI NCBI:14828