Hspa5 - heat shock protein family A (Hsp70) member 5 Gene

Also Known as BIP; GRP78; GRP 78

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25617

About Hspa5

Primary_assembly 3: 18,055,405-18,059,891 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 257 orthologues, 13 paralogues and is associated with 37 phenotypes. Biased expression in Liver (RPKM 2693.8), Heart (RPKM 215.3) and 9 other tissues.

Summary

Enables misfolded protein binding activity and unfolded protein binding activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and cellular response to metal ion. Acts upstream of or within response to endoplasmic reticulum stress. Located in membrane; mitochondrion; and smooth endoplasmic reticulum. Biomarker of fatty liver disease; post-traumatic stress disorder; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (HSP70) member 5). [provided by Alliance of Genome Resources, Apr 2022]

Hspa5 Products (1)

mRNA Protein Name
NM_013083.2 NP_037215.1 endoplasmic reticulum chaperone BiP precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables misfolded protein binding IDA
IDA: Inferred from direct assay
23444373 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7916014 RGD
enables unfolded protein binding IPI
IPI: Inferred from physical interaction
11884402 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to antibiotic IEP
IEP: Inferred from expression pattern
19332540 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
9058202 RGD
involved in cellular response to calcium ion IEP
IEP: Inferred from expression pattern
9058202 RGD
involved in cellular response to gamma radiation IEP
IEP: Inferred from expression pattern
20470193 RGD
involved in cellular response to manganese ion IEP
IEP: Inferred from expression pattern
23934647 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
10936191 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18757512 RGD
involved in luteolysis IEP
IEP: Inferred from expression pattern
25332219 RGD
involved in neuron apoptotic process IEP
IEP: Inferred from expression pattern
9058202 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
19322020 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
10936191 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
17849098 RGD
acts upstream of or within response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
23444373 RGD
involved in response to endoplasmic reticulum stress IEP
IEP: Inferred from expression pattern
22189689 RGD
involved in response to methamphetamine hydrochloride IEP
IEP: Inferred from expression pattern
19826936 RGD
involved in stress response to metal ion IEP
IEP: Inferred from expression pattern
17915553 RGD
Cellular Component GO Annotation Evidence References Source
located in dendritic shaft IDA
IDA: Inferred from direct assay
26088419 RGD
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19474315 RGD
located in membrane IDA
IDA: Inferred from direct assay
23444373 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
26088419 RGD
located in smooth endoplasmic reticulum IDA
IDA: Inferred from direct assay
22665516 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hspa5 Protein Structure

HSP70

HSP70: pfam00012 (29 - 634)

  • 0
  • 200
  • 400
  • 600
  • 654 a.a.
Protein Preferred Names Protein Names

endoplasmic reticulum chaperone BiP

  • 78 kDa glucose-regulated protein

  • GRP-78

  • HSP70 family protein 5

  • binding-immunoglobulin protein

  • heat shock 70 kDa protein 5

  • heat shock 70kD protein 5

  • heat shock 70kDa protein 5 (glucose-regulated protein)

  • heat shock protein 5

  • heat shock protein 70 family protein 5

  • heat shock protein family A member 5

  • immunoglobulin heavy chain-binding protein

  • steroidogenesis-activator polypeptide

Hspa5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Hspa5 P06761 Tg Rattus norvegicus P06882
Density Sedimentation
7916014
Intra
Hspa5 P06761 Sigmar1 Rattus norvegicus Q9R0C9
Pull Down
17981125
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W250122 Glutamic acid sodium salt Activator 99.92% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125974 HM03 Inhibitor 99.51% Unkown
HY-152153 GRP78-IN-3 Inhibitor 99.88% Unkown
HY-125974A HM03 trihydrochloride Inhibitor / Unkown
HY-184982 Estrogen receptor-IN-2 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspa5 NCBI NCBI:3309