Pak3 - p21 (RAC1) activated kinase 3 Gene

Also Known as beta-PAK

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29433

About Pak3

Primary_assembly X: 107,260,898-107,368,314 forward strand.mRatBN7.2:CM026994.1

This gene has 4 transcripts (splice variants), 213 orthologues, 36 paralogues and is associated with 9 phenotypes. Biased expression in Brain (RPKM 136.9), Testes (RPKM 64.9) and 2 other tissues.

Summary

Enables GTPase binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of dendritic spine morphogenesis; and positive regulation of fibroblast migration. Located in endosome. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Pak3 Products (1)

mRNA Protein Name
NM_019210.2 NP_062083.1 serine/threonine-protein kinase PAK 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase binding IDA
IDA: Inferred from direct assay
7559638 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
7559638 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9823899 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
12890786 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
18481281 RGD
involved in positive regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
23818969 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
12890786 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9823899 RGD
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
23818969 RGD
involved in regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
15574732 RGD
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
12890786 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pak3 Protein Structure

PBD

PBD: pfam00786 (68 - 161)

STKc_PAK3

STKc_PAK3: cd06656 (283 - 579)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 580 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 3

  • PAK-3

  • p21 (CDKN1A)-activated kinase 3

  • p21 protein (Cdc42/Rac)-activated kinase 3

  • p21-activated kinase 3

  • p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related)

  • p65-PAK

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15542A FRAX597 Inhibitor 99.36% Unkown
HY-15542B FRAX486 Inhibitor 98.10% Unkown
HY-123739 LDN-0028574 Inhibitor / Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown
HY-146786 ZMF-10 Inhibitor / Unkown
HY-178812 PI3Kα-IN-27 Inhibitor / Unkown
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-184447 RN193 Inhibitor / Unkown
HY-118606 LDN-0044878 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pak3 NCBI NCBI:5063