PAK3 - p21 (RAC1) activated kinase 3 Gene

Also Known as ARA; bPAK; MRX30; MRX47; OPHN3; PAK-3; XLID30; PAK3beta; beta-PAK

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5063

About PAK3

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:110,944,397-111,227,361 (from NCBI)

This gene has 12 transcripts (splice variants), 213 orthologues, 35 paralogues and is associated with 4 phenotypes. Biased expression in brain (RPKM 8.0), pancreas (RPKM 3.0) and 11 other tissues.

Summary

The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]

PAK3 Products (43)

mRNA Protein Name
XM_047442149.1 XP_047298105.1 serine/threonine-protein kinase PAK 3 isoform X4
NR_136740.2
NM_001324326.2 NP_001311255.1 serine/threonine-protein kinase PAK 3 isoform a
NM_001324329.2 NP_001311258.1 serine/threonine-protein kinase PAK 3 isoform d
XM_047442146.1 XP_047298102.1 serine/threonine-protein kinase PAK 3 isoform X3
NM_001324325.2 NP_001311254.1 serine/threonine-protein kinase PAK 3 isoform a
NR_136744.2
XM_011530971.3 XP_011529273.1 serine/threonine-protein kinase PAK 3 isoform X6
XM_017029558.2 XP_016885047.1 serine/threonine-protein kinase PAK 3 isoform X3
XM_047442147.1 XP_047298103.1 serine/threonine-protein kinase PAK 3 isoform X3
XM_005262133.4 XP_005262190.1 serine/threonine-protein kinase PAK 3 isoform X3
NM_002578.5 NP_002569.1 serine/threonine-protein kinase PAK 3 isoform a
NM_001128168.3 NP_001121640.1 serine/threonine-protein kinase PAK 3 isoform b
NM_001324330.2 NP_001311259.1 serine/threonine-protein kinase PAK 3 isoform a
NM_001324332.2 NP_001311261.1 serine/threonine-protein kinase PAK 3 isoform a
XM_006724655.3 XP_006724718.1 serine/threonine-protein kinase PAK 3 isoform X1
NR_136747.2
NR_136746.2
NR_136741.2
NM_001128167.3 NP_001121639.1 serine/threonine-protein kinase PAK 3 isoform a
XM_047442148.1 XP_047298104.1 serine/threonine-protein kinase PAK 3 isoform X4
NM_001128173.3 NP_001121645.1 serine/threonine-protein kinase PAK 3 isoform d
NR_136743.2
XM_047442150.1 XP_047298106.1 serine/threonine-protein kinase PAK 3 isoform X5
XM_011530969.2 XP_011529271.1 serine/threonine-protein kinase PAK 3 isoform X1
XM_017029557.2 XP_016885046.1 serine/threonine-protein kinase PAK 3 isoform X2
NR_136742.2
NM_001324328.2 NP_001311257.1 serine/threonine-protein kinase PAK 3 isoform d
NM_001324333.2 NP_001311262.1 serine/threonine-protein kinase PAK 3 isoform d
NM_001128166.3 NP_001121638.1 serine/threonine-protein kinase PAK 3 isoform a
NM_001128172.2 NP_001121644.1 serine/threonine-protein kinase PAK 3 isoform c
NM_001324334.2 NP_001311263.1 serine/threonine-protein kinase PAK 3 isoform a
XM_005262132.3 XP_005262189.1 serine/threonine-protein kinase PAK 3 isoform X1
XM_017029559.2 XP_016885048.1 serine/threonine-protein kinase PAK 3 isoform X3
XM_011530968.3 XP_011529270.1 serine/threonine-protein kinase PAK 3 isoform X1
NM_001324327.2 NP_001311256.1 serine/threonine-protein kinase PAK 3 isoform d
XM_006724654.3 XP_006724717.1 serine/threonine-protein kinase PAK 3 isoform X1
NR_136745.2
XM_017029563.2 XP_016885052.1 serine/threonine-protein kinase PAK 3 isoform X7
XM_017029560.2 XP_016885049.1 serine/threonine-protein kinase PAK 3 isoform X3
NM_001324331.2 NP_001311260.1 serine/threonine-protein kinase PAK 3 isoform a
XM_011530962.2 XP_011529264.1 serine/threonine-protein kinase PAK 3 isoform X1
NR_136748.1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables MAP kinase kinase activity IDA
IDA: Inferred from direct assay
21177870 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
21177870 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAK3 Protein Structure

PBD

PBD: P21-Rho-binding domain (69 - 141)

Pkinase

Pkinase: Protein kinase domain (283 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 559 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 3

  • adriamycin resistance-associated

  • oligophrenin-3

  • p21 (CDKN1A)-activated kinase 3

  • p21 protein (Cdc42/Rac)-activated kinase 3

PAK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PAK3 O75914 CDC42 Homo sapiens P60953-2
Y2H
11157984
Intra
PAK3 O75914 CDC42 Homo sapiens P60953-2
Far-WB
11157984
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PAK3 Proteins

Cat. No. Product Name Accession Purity
HY-P74654 PAK3 Protein, Human (Active, sf9, His) O75914-2 (M1-R544) ≥ 80%, as determined by reducing SDS-PAGE.

PAK3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81622 PAK3 Antibody (YA1367) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P81785 Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (YA1530) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P81785A Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (YA1530)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P83870 PAK3 Antibody (YA3567) WB, ELISA Human, Monkey
HY-P83870A PAK3 Antibody (YA3567)(PBS only) WB, ELISA Human, Monkey

Related Diseases

Diseases Alias
Endometrial Cancer

  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer
Non-Syndromic X-Linked Intellectual Disability 30

  • Mrx30

  • Mrx47

  • X-Linked Mental Retardation 30/47

  • X-Linked Mental Retardation 47

  • Mental Retardation, X-Linked, Type 30/47
Cerebral Palsy

  • Infantile Cerebral Palsy

  • Mixed Cerebral Palsy

  • Palsy Cerebral

  • Palsy, Cerebral

  • Cerebral Palsy, Mixed
Syndromic Intellectual Disability
Tetanus Neonatorum

  • Neonatal Tetanus

  • NNT

  • Trismus Neonatorum

  • Newborn Trismus
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Intellectual Developmental Disorder, X-Linked 30

  • XLID30

  • Mrx30

  • Mental Retardation, X-Linked 47

  • Mrx47

  • Mental Retardation, X-Linked 30
Endometrial Clear Cell Adenocarcinoma

  • Clear Cell Carcinoma Of Endometrium
Non-Syndromic X-Linked Intellectual Disability

  • X-Linked Non-Syndromic Intellectual Disability

  • Non-Specific X-Linked Mental Retardation

  • X-Linked Non-Specific Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15542A FRAX597 Inhibitor 99.36% Unkown
HY-15542B FRAX486 Inhibitor 98.10% Unkown
HY-123739 LDN-0028574 Inhibitor / Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown
HY-146786 ZMF-10 Inhibitor / Unkown
HY-178812 PI3Kα-IN-27 Inhibitor / Unkown
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-184447 RN193 Inhibitor / Unkown
HY-118606 LDN-0044878 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PAK3 VGNC VGNC:53550
Mus musculus PAK3 MGD MGI:1339656
Bos taurus PAK3 VGNC VGNC:53659
Rattus norvegicus PAK3 RGD RGD:3251
Others PAK3 NCBI