Ghrh - growth hormone releasing hormone Gene

Also Known as GHRF

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29446

Summary

Enables growth hormone-releasing hormone activity. Involved in several processes, including circadian sleep/wake cycle, non-REM sleep; growth hormone secretion; and positive regulation of cell communication. Located in axon terminus; extracellular space; and perikaryon. Used to study myocardial infarction and prostatic hypertrophy. Biomarker of sleep disorder. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome type 1; endometrial cancer; ovarian cancer; and renal cell carcinoma. Orthologous to human GHRH (growth hormone releasing hormone). [provided by Alliance of Genome Resources, Apr 2022]

Ghrh Products (1)

mRNA	Protein	Name
NM_031577.1	NP_113765.1	somatoliberin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables growth hormone-releasing hormone activity	IDA IDA: Inferred from direct assay	12446584	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12446584	RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	14664705	RGD
involved in cellular response to interleukin-6	IEP IEP: Inferred from expression pattern	19239705	RGD
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19293247	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14664705	RGD
involved in positive regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	10579333	RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep	IMP IMP: Inferred from mutant phenotype	19889861	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	12213318	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	18363807	RGD
involved in positive regulation of growth hormone secretion	IDA IDA: Inferred from direct assay	6130528	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	22067322	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	21180161	RGD
involved in response to leptin	IEP IEP: Inferred from expression pattern	18806317	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon terminus	IDA IDA: Inferred from direct assay	6423368	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	1537276	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	6423368	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
somatoliberin	GRF growth hormone-releasing factor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0089A	Human growth hormone-releasing factor TFA	Activator	99.49%	Unkown
HY-P3304	MR 409	Agonist	99.98%	Unkown
HY-P3397A	JV-1-36 acetate	Antagonist	99.93%	Unkown
HY-P0089	Human growth hormone-releasing factor	Activator	98.63%	Unkown
HY-P3397	JV-1-36	Antagonist	/	Unkown
HY-P3594	[His1,Nle27] GHRF (1-32), amide, human	Activator	/	Unkown
HY-P3595	GHRF, porcine	Activator	/	Unkown
HY-RS05413	GHRH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16752	Ghrh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23191	Ghrh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ghrh	NCBI	NCBI:2691