Skp2 - S-phase kinase associated protein 2 Gene

Also Known as RGD1562456

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 294790

Summary

Predicted to enable identical protein binding activity. Involved in cellular response to cell-matrix adhesion and positive regulation of smooth muscle cell proliferation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of SCF ubiquitin Ligase complex. Predicted to be active in cytosol and nucleus. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Skp2 Products (1)

mRNA Protein Name
NM_001106416.2 NP_001099886.1 S-phase kinase-associated protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19533683 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to cell-matrix adhesion IEP
IEP: Inferred from expression pattern
11425869 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
19878790 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

S-phase kinase-associated protein 2

  • S-phase kinase-associated protein 2 (p45)

  • S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0256 Hederagenin Ligand 99.95% Unkown
HY-153937 Skp2 inhibitor 2 Inhibitor 99.88% Unkown
HY-162938 Skp2 inhibitor 3 Inhibitor 98.07% Unkown
HY-181653 PROTAC SKP2 Degrader-1 Degrader 99.91% Unkown
HY-P11792 CP2-CPP / Unkown
HY-129108 9-cis-UAB30 Inhibitor / Unkown
HY-P11020 p27 Analogue CP2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Skp2 NCBI NCBI:6502