Notch2 - notch receptor 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29492

Summary

Predicted to enable NF-kappaB binding activity and enzyme binding activity. Involved in cell fate determination; tissue regeneration; and wound healing. Predicted to be located in several cellular components, including cell surface; cilium; and nucleoplasm. Predicted to be integral component of plasma membrane. Predicted to be part of receptor complex. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (Notch receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Notch2 Products (1)

mRNA Protein Name
NM_024358.2 NP_077334.2 neurogenic locus notch homolog protein 2 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in brain development IEP
IEP: Inferred from expression pattern
1295745 RGD
involved in tissue regeneration IEP
IEP: Inferred from expression pattern
16118793 RGD
involved in wound healing IEP
IEP: Inferred from expression pattern
11549580 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
27565350 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
27565350 RGD
is active in postsynaptic density membrane EXP
EXP: Inferred from Experiment
27565350 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
27565350 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurogenic locus notch homolog protein 2

  • notch 2

  • notch gene homolog 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15670 BMS-906024 Inhibitor 99.91% Phase 1
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99320 Tarextumab Inhibitor 99.83% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N6727 Gliotoxin 99.51% Unkown
HY-RS09448 NOTCH2 Human Pre-designed siRNA Set A / Unkown
HY-RS09450 NOTCH2NLC Human Pre-designed siRNA Set A / Unkown
HY-RS19796 Notch2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09449 NOTCH2NLA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26292 Notch2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990206 Anti-Mouse Jagged 2 Antibody (HMJ2-1) Inhibitor / Unkown
HY-P992278 Anti-Notch2 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Notch2 NCBI NCBI:4853