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Hif1a - hypoxia inducible factor 1 subunit alpha Gene

Also Known as MOP1; HIF1-alpha

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29560

Summary

Enables sequence-specific DNA binding activity and ubiquitin protein Ligase binding activity. Involved in several processes, including cellular response to carbon monoxide; regulation of apoptotic process; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Used to study acute kidney failure; brain ischemia; diabetic retinopathy; hepatocellular carcinoma; and middle cerebral artery infarction. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; decubitus ulcer; ischemia (multiple); and kidney failure (multiple). Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Hif1a Products (1)

mRNA	Protein	Name
NM_024359.2	NP_077335.2	hypoxia-inducible factor 1-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19950214	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11029639	RGD
enables protein-containing complex binding	IMP IMP: Inferred from mutant phenotype	10559391	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15084519	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18614764	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19950214	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in acute-phase response	IEP IEP: Inferred from expression pattern	19840250	RGD
involved in cellular response to anoxia	IEP IEP: Inferred from expression pattern	18614764	RGD
involved in cellular response to carbon monoxide	IEP IEP: Inferred from expression pattern	17475674	RGD
involved in cellular response to cobalt ion	IEP IEP: Inferred from expression pattern	10559391	RGD
involved in cellular response to cyanide	IEP IEP: Inferred from expression pattern	21854848	RGD
involved in cellular response to electrical stimulus	IEP IEP: Inferred from expression pattern	12193088	RGD
involved in cellular response to estrogen stimulus	IEP IEP: Inferred from expression pattern	17272396	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	12234775	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	16735674	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	19220706	RGD
involved in cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	18248612	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	16506055	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	12101082	RGD
involved in cellular response to light stimulus	IEP IEP: Inferred from expression pattern	17475674	RGD
involved in cellular response to lipid	IEP IEP: Inferred from expression pattern	19423865	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19940979	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	15183444	RGD
involved in cellular response to nitrite	IEP IEP: Inferred from expression pattern	23227543	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	9398602	RGD
involved in cellular response to toxic substance	IEP IEP: Inferred from expression pattern	21854848	RGD
involved in cellular response to wortmannin	IEP IEP: Inferred from expression pattern	17272396	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20193759	RGD
involved in iron import into the mitochondrion	IMP IMP: Inferred from mutant phenotype	26071548	RGD
involved in maternal process involved in female pregnancy	IEP IEP: Inferred from expression pattern	20181619	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20498255	RGD
involved in negative regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	26071548	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20496369	RGD
involved in negative regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	21106323	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20224844	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11029639	RGD
involved in positive regulation of cell size	IEP IEP: Inferred from expression pattern	22129453	RGD
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	30052311	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19220706	RGD
involved in positive regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	24177414	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	16489407	RGD
involved in positive regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	30052311	RGD
involved in positive regulation of stress granule assembly	IMP IMP: Inferred from mutant phenotype	30404558	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11237857	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20496369	RGD
involved in positive regulation of vascular endothelial growth factor production	IMP IMP: Inferred from mutant phenotype	18614764	RGD
involved in positive regulation of vascular wound healing	IMP IMP: Inferred from mutant phenotype	30052311	RGD
involved in regulation of cellular response to hypoxia	IEP IEP: Inferred from expression pattern	18054269	RGD
involved in response to X-ray	IEP IEP: Inferred from expression pattern	15161688	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	19913571	RGD
involved in response to alkaloid	IEP IEP: Inferred from expression pattern	15067214	RGD
involved in response to anesthetic	IEP IEP: Inferred from expression pattern	18218685	RGD
involved in response to auditory stimulus	IEP IEP: Inferred from expression pattern	19840840	RGD
involved in response to cobalt ion	IEP IEP: Inferred from expression pattern	19384568	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	17716391	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	20487002	RGD
involved in response to fungicide	IMP IMP: Inferred from mutant phenotype	18347136	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	18385541	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	12189448	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	12388599	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	21106323	RGD
involved in response to purine-containing compound	IEP IEP: Inferred from expression pattern	18248612	RGD
involved in response to salt stress	IEP IEP: Inferred from expression pattern	20232302	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	14574457	RGD
involved in tissue remodeling	IEP IEP: Inferred from expression pattern	23887904	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	18614764	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
hypoxia-inducible factor 1-alpha	HIF1 alpha hypoxia inducible factor 1 alpha subunit hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0657	Pinoresinol Diglucoside		99.84%	Unkown
HY-RS06168	HIF1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-112068	DM-NOFD	Inhibitor	99.81%	Unkown
HY-100947A	cis VH-298		99.96%	Unkown
HY-RS16959	Hif1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-123255	BSc2118		/	Unkown
HY-161838	ICT10336	Inhibitor	/	Unkown
HY-N13009	MO-2097		/	Unkown
HY-RS23402	Hif1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hif1a	NCBI	NCBI:3091