Map2k5 - mitogen activated protein kinase kinase 5 Gene

Also Known as Mek5

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29568

About Map2k5

Primary_assembly 8: 63,625,221-63,851,983 reverse strand.mRatBN7.2:CM026981.1

This gene has 4 transcripts (splice variants), 209 orthologues, 8 paralogues and is associated with 9 phenotypes.

Summary

Enables ATP binding activity and protein kinase activity. Involved in several processes, including ERK5 cascade; negative regulation of apoptotic process; and regulation of gene expression. Located in cytosol and nucleus. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Map2k5 Products (2)

mRNA Protein Name
NM_001033987.1 NP_001029159.1 dual specificity mitogen-activated protein kinase kinase 5 isoform a
NM_017246.2 NP_058942.1 dual specificity mitogen-activated protein kinase kinase 5 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
7499418 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
7499418 RGD
Biological Process GO Annotation Evidence References Source
involved in ERK5 cascade IMP
IMP: Inferred from mutant phenotype
15631999 RGD
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
20551324 RGD
involved in cellular response to growth factor stimulus IMP
IMP: Inferred from mutant phenotype
20551324 RGD
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
20551324 RGD
involved in negative regulation of cell migration involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
20551324 RGD
involved in negative regulation of chemokine (C-X-C motif) ligand 2 production IMP
IMP: Inferred from mutant phenotype
20551324 RGD
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
20551324 RGD
involved in negative regulation of heterotypic cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
20551324 RGD
involved in negative regulation of interleukin-8 production IMP
IMP: Inferred from mutant phenotype
20551324 RGD
involved in negative regulation of response to cytokine stimulus IMP
IMP: Inferred from mutant phenotype
20551324 RGD
involved in negative regulation of smooth muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
20724525 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20551324 RGD
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
15623435 RGD
involved in positive regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
15631999 RGD
involved in positive regulation of protein metabolic process IMP
IMP: Inferred from mutant phenotype
20551324 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20551324 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
7499418 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 5

  • MAP kinase kinase 5

  • MAPK/ERK kinase 5

  • MAPKK 5

  • MEK 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08041 MAP2K5 Human Pre-designed siRNA Set A / Unkown
HY-RS08042 Map2k5 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08043 Map2k5 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2k5 NCBI NCBI:5607