GYPA - glycophorin A (MNS blood group) Gene
Also Known as MN; GPA; MNS; GPSAT; PAS-2; CD235a; GPErik; HGpMiV; HGpMiXI; HGpSta(C)
Species: Homo sapiens
About GYPA
This gene has 20 transcripts (splice variants), 35 orthologues, 2 paralogues and is associated with 2 phenotypes. Restricted expression toward bone marrow (RPKM 31.9).
Summary
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008]
GYPA Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001308187.2 | NP_001295116.1 | glycophorin-A isoform 2 precursor |
| NM_001308190.2 | NP_001295119.1 | glycophorin-A isoform 3 |
| NM_002099.8 | NP_002090.4 | glycophorin-A isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
15067009 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
19438409 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of ankyrin-1 complex |
IDA
IDA: Inferred from direct assay
|
35835865 | GOA |
GYPA Protein Structure
Glycophorin_A: Glycophorin A (28 - 147)
- 0
- 100
- 150 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
glycophorin-A |
|
GYPA Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
GYPA | P02724 | IL10RA | Homo sapiens | Q13651 | 32296183 | |
|
Intra
|
GYPA | P02724 | IL10RA | Homo sapiens | Q13651 | 32296183 | |
|
Intra
|
GYPA | P02724 | IL10RA | Homo sapiens | Q13651 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMBIM6 | Homo sapiens | P55061 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM237 | Homo sapiens | Q96Q45-2 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM237 | Homo sapiens | Q96Q45-2 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM237 | Homo sapiens | Q96Q45-2 | 32296183 | |
|
Intra
|
GYPA | P02724 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
GYPA | P02724 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
GYPA | P02724 | TLCD4 | Homo sapiens | Q96MV1 | 32296183 | |
|
Intra
|
GYPA | P02724 | TLCD4 | Homo sapiens | Q96MV1 | 32296183 | |
|
Intra
|
GYPA | P02724 | TLCD4 | Homo sapiens | Q96MV1 | 32296183 | |
|
Intra
|
GYPA | P02724 | GPRC5D | Homo sapiens | Q9NZD1 | 32296183 | |
|
Intra
|
GYPA | P02724 | GPRC5D | Homo sapiens | Q9NZD1 | 32296183 | |
|
Intra
|
GYPA | P02724 | GPRC5D | Homo sapiens | Q9NZD1 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM154 | Homo sapiens | Q6P9G4 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM154 | Homo sapiens | Q6P9G4 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM154 | Homo sapiens | Q6P9G4 | 32296183 | |
|
Intra
|
GYPA | P02724 | GOLT1A | Homo sapiens | Q6ZVE7 | 32296183 | |
|
Intra
|
GYPA | P02724 | GOLT1A | Homo sapiens | Q6ZVE7 | 32296183 | |
|
Intra
|
GYPA | P02724 | GOLT1A | Homo sapiens | Q6ZVE7 | 32296183 | |
|
Intra
|
GYPA | P02724 | ANKRD29 | Homo sapiens | Q8N6D5 | 32296183 | |
|
Intra
|
GYPA | P02724 | ANKRD29 | Homo sapiens | Q8N6D5 | 32296183 | |
|
Intra
|
GYPA | P02724 | ANKRD29 | Homo sapiens | Q8N6D5 | 32296183 | |
|
Intra
|
GYPA | P02724 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
GYPA | P02724 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
GYPA | P02724 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
GYPA | P02724 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
GYPA | P02724 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
GYPA | P02724 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
GYPA | P02724 | CLDN5 | Homo sapiens | O00501 | 32296183 | |
|
Intra
|
GYPA | P02724 | CLDN5 | Homo sapiens | O00501 | 32296183 | |
|
Intra
|
GYPA | P02724 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
GYPA | P02724 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
GYPA | P02724 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Cross
|
GYPA | P02724 | EBP | Plasmodium reichenowi | Q9N9G9 | 24297912 | |
|
Cross
|
GYPA | P02724 | EBP | Plasmodium reichenowi | Q9N9G9 | 24297912 | |
|
Intra
|
GYPA | P02724 | EBA-175 | Plasmodium sp. chimpanzee clade C3 | V9XTM1 | 24297912 | |
|
Intra
|
GYPA | P02724 | EBA-175 | Plasmodium sp. chimpanzee clade C3 | V9XTM1 | 24297912 | |
|
Intra
|
GYPA | P02724 | FFAR2 | Homo sapiens | O15552 | 32296183 | |
|
Intra
|
GYPA | P02724 | FFAR2 | Homo sapiens | O15552 | 32296183 | |
|
Intra
|
GYPA | P02724 | LAPTM5 | Homo sapiens | Q13571 | 32296183 | |
|
Intra
|
GYPA | P02724 | LAPTM5 | Homo sapiens | Q13571 | 32296183 | |
|
Intra
|
GYPA | P02724 | LAPTM5 | Homo sapiens | Q13571 | 32296183 | |
|
Intra
|
GYPA | P02724 | SGTA | Homo sapiens | O43765 | 32296183 | |
|
Intra
|
GYPA | P02724 | SGTA | Homo sapiens | O43765 | 32296183 | |
|
Intra
|
GYPA | P02724 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
GYPA | P02724 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
GYPA | P02724 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
GYPA | P02724 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
GYPA | P02724 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
GYPA | P02724 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
GYPA | P02724 | SLC4A1 | Homo sapiens | P02730 | 19438409 | |
|
Intra
|
GYPA | P02724 | ccsb orf id: 2260 | Homo sapiens | EBI-22326698 | 32296183 | |
|
Intra
|
GYPA | P02724 | SLC4A1 | Homo sapiens | P02730 | 19438409 | |
|
Intra
|
GYPA | P02724 | SLC4A1 | Homo sapiens | P02730 | 19438409 | |
|
Intra
|
GYPA | P02724 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
GYPA | P02724 | GYPA | Homo sapiens | P02724 | 23155421 | |
|
Intra
|
GYPA | P02724 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
GYPA | P02724 | GYPA | Homo sapiens | P02724 | 14681217 | |
|
Intra
|
GYPA | P02724 | ccsb orf id: 2260 | Homo sapiens | EBI-22326698 | 32296183 | |
|
Intra
|
GYPA | P02724 | GYPA | Homo sapiens | P02724 | 15067009 | |
|
Intra
|
GYPA | P02724 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
GYPA | P02724 | EVA1A | Homo sapiens | Q9H8M9 | 32296183 | |
|
Intra
|
GYPA | P02724 | EVA1A | Homo sapiens | Q9H8M9 | 32296183 | |
|
Intra
|
GYPA | P02724 | EVA1A | Homo sapiens | Q9H8M9 | 32296183 | |
|
Intra
|
GYPA | P02724 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
GYPA | P02724 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
GYPA | P02724 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
GYPA | P02724 | SGTB | Homo sapiens | Q96EQ0 | 32296183 | |
|
Intra
|
GYPA | P02724 | SGTB | Homo sapiens | Q96EQ0 | 32296183 | |
|
Intra
|
GYPA | P02724 | SGTB | Homo sapiens | Q96EQ0 | 32296183 | |
|
Intra
|
GYPA | P02724 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
GYPA | P02724 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
GYPA | P02724 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Cross
|
GYPA | P02724 | q8ibe8_plaf7 | Plasmodium falciparum | Q8IBE8 | 24297912 | |
|
Cross
|
GYPA | P02724 | q8ibe8_plaf7 | Plasmodium falciparum | Q8IBE8 | 24297912 |
Recombinant GYPA Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P71741 | GYPA/CD235a Protein, Human (P.pastoris, His) | A0A0C4DFT7 (L20-E91) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P72218 | GYPA/CD235a Protein, Human (GST) | A0A0C4DFT7 (L20-E91) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P72219 | GYPA/CD235a Protein, Human (His) | A0A0C4DFT7 (L20-E91) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P75151 | GYPA/CD235a Protein, Human (E24G, HEK293, His) | P02724-1 (S21-E91, E24G) | ≥ 95%, as determined by reducing SDS-PAGE. |
GYPA Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81406 | Glycophorin A Antibody (YA1151) | IHC-P | Human |
| HY-P81406A | Glycophorin A Antibody (YA1151)(PBS only) | IHC-P | Human |
| HY-P83666M | Human CD235 Antibody (APC) (YA3400) | FC | Human |
| HY-P85916 | Glycophorin A Antibody (YA5608) | IHC-P, WB, ICC/IF, ELISA | Human |
| HY-P87180 | CD235a Antibody (YA6871) | FC, ELISA | Human |
| HY-P87180A | CD235a Antibody (YA6871)(PBS only) | FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Malaria |
|
|
| Hepatitis A |
|
|
| Pyridoxine-Responsive Sideroblastic Anemia |
|
|
| Hereditary Spherocytosis |
|
|
| Anemia, Autoimmune Hemolytic |
|
|
| Gastric Teratoma |
|
|
| Acute Erythroid Leukemia |
|
|
| Malignant Gastric Germ Cell Tumor |
|
|
| Diamond-Blackfan Anemia |
|
|
| Anemia, Congenital Dyserythropoietic, Type Ia |
|
|
| Carrion'S Disease |
|
|
| Hereditary Elliptocytosis |
|
|
| Duodenum Adenoma |
|
|
| Myelodysplastic Syndrome |
|
|
| Fetal Erythroblastosis |
|
|
| Myasthenic Syndrome, Congenital, 3a, Slow-Channel |
|
|
| Congenital Hemolytic Anemia |
|
|
| Anemia Of Prematurity |
|
|
| Myeloproliferative Syndrome, Transient |
|
|
| Sickle Cell Anemia |
|
|
| Hemoglobinopathy |
|
|
| Plasmodium Vivax Malaria |
|
|
| Beta-Thalassemia Major |
|
|
| Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Hemoglobin D Disease |
|
|
| Glucosephosphate Dehydrogenase Deficiency |
|
|
| Hemolytic Anemia |
|
|
| Deficiency Anemia |
|
|
| Leukemia, Acute Myeloid |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | GYPA | RGD | RGD:1582935 |
| Mus musculus | GYPA | MGD | MGI:95880 |
| Others | GYPA | NCBI |