APH1B - Aph1b aph-1 homolog B, gamma secretase subunit Gene

Also Known as APH-1B'

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 300802

Summary

Predicted to enable endopeptidase activator activity and protein-macromolecule adaptor activity. Involved in locomotory behavior. Predicted to be located in transport vesicle. Predicted to be part of gamma-secretase complex. Predicted to be active in endoplasmic reticulum. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human APH1B (aph-1 homolog B, gamma-secretase subunit). [provided by Alliance of Genome Resources, Apr 2022]

APH1B Products (1)

mRNA Protein Name
NM_001047090.2 NP_001040555.1 gamma-secretase subunit APH-1B

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in locomotory behavior IMP
IMP: Inferred from mutant phenotype
15721236 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-secretase subunit APH-1B

  • APH1B gamma secretase subunit

  • anterior pharynx defective 1 homolog B

  • anterior pharynx defective 1b homolog

  • gamma-secretase subunit APH-1B-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156012 PSEN1-IN-2 Inhibitor / Unkown
HY-156011 PSEN1-IN-1 Inhibitor / Unkown
HY-RS00818 APH1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22392 Aph1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28916 Aph1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens APH1B NCBI NCBI:83464