MFF - Mff mitochondrial fission factor Gene

Also Known as RGD1310230

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 301563

Summary

Enables GTPase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of cellular component organization. Located in synaptic vesicle. Colocalizes with mitochondrial membrane and synaptic vesicle membrane. Used to study transient cerebral ischemia. Orthologous to human MFF (mitochondrial fission factor). [provided by Alliance of Genome Resources, Apr 2022]

MFF Products (3)

mRNA Protein Name
NM_001039015.2 NP_001034104.1 mitochondrial fission factor isoform 2
NM_001271284.1 NP_001258213.1 mitochondrial fission factor isoform 1
NM_001276401.1 NP_001263330.1 mitochondrial fission factor isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
23792689 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
23792689 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
23792689 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
23867156 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
23867156 RGD
involved in positive regulation of mitochondrial fission IMP
IMP: Inferred from mutant phenotype
23867156 RGD
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
23792689 RGD
involved in protein targeting to mitochondrion IMP
IMP: Inferred from mutant phenotype
23792689 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial membrane IMP
IMP: Inferred from mutant phenotype
23792689 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
23792689 RGD
located in synaptic vesicle membrane IMP
IMP: Inferred from mutant phenotype
23792689 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial fission factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139109 IR-783 99.46% Unkown
HY-P6374 IIQLPEIVVV TFA 99.28% Unkown
HY-P11005 P259 Inhibitor 99.75% Unkown
HY-101433 N-Acetylprocainamide hydrochloride Inhibitor 99.83% Yes
HY-RS08380 MFF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19299 Mff Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25790 Mff Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens MFF NCBI NCBI:56947