Kat2a - lysine acetyltransferase 2A Gene

Also Known as Gcn5; Gcn5l2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 303539

About Kat2a

Primary_assembly 10: 85,632,216-85,640,166 reverse strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 209 orthologues, 11 paralogues and is associated with 4 phenotypes. Biased expression in Brain (RPKM 66.2), Adrenal (RPKM 57.9) and 9 other tissues.

Summary

Enables chromatin binding activity and protein Phosphatase binding activity. Involved in several processes, including alpha-tubulin acetylation; intracellular distribution of mitochondria; and positive regulation of cardiac muscle cell differentiation. Located in chromatin and nucleus. Orthologous to human KAT2A (lysine acetyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Kat2a Products (1)

mRNA	Protein	Name
NM_001107050.1	NP_001100520.1	histone acetyltransferase KAT2A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	21697636	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17334388	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	15496412	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in alpha-tubulin acetylation	IMP IMP: Inferred from mutant phenotype	20691906	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	15496412	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	20130956	RGD
involved in intracellular distribution of mitochondria	IMP IMP: Inferred from mutant phenotype	19542216	RGD
involved in positive regulation of cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	20835911	RGD
involved in positive regulation of cell projection organization	IMP IMP: Inferred from mutant phenotype	20691906	RGD
involved in protein modification process	IMP IMP: Inferred from mutant phenotype	20835911	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	21697636	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	24614236	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	20130956	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kat2a Protein Structure

PCAF_N

COG5076

Bromo_gcn5_like

0
200
400
600
833 a.a.

Protein Preferred Names	Protein Names
histone acetyltransferase KAT2A	GCN5 general control of amino acid synthesis-like 2 K(lysine) acetyltransferase 2A general control of amino acid synthesis 5-like 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173158	AUR1545	Inhibitor	99.58%	Unkown
HY-122822	GSK699		98.80%	Unkown
HY-168428	CHI-KAT8i5		98.00%	Unkown
HY-RS07074	KAT2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07075	Kat2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181695	PROTAC KAT2A/B degrader-1	Degrader	/	Unkown
HY-RS07076	Kat2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W1122565	KAT2A/B ligand 1	Ligand	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kat2a	NCBI	NCBI:2648