2. Gene
  3. Ezh1 - enhancer of zeste 1 polycomb repressive complex 2 subunit Gene

Ezh1 - enhancer of zeste 1 polycomb repressive complex 2 subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 303547 | Gene type: protein coding

About Ezh1

Primary_assembly 10: 86,126,015-86,161,921 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 234 orthologues and 23 paralogues. Biased expression in Kidney (RPKM 177.3), Lung (RPKM 163.3) and 9 other tissues.

Summary

Enables chromatin binding activity. Involved in hippocampus development and positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ezh1 Products(1)

mRNA Protein Name
NM_001107051.1 NP_001100521.1 histone-lysine N-methyltransferase EZH1

Ezh1 Protein Structure

EZH2_WD-Binding

EZH2_WD-Binding: pfam11616 (38 - 67)

PRC2_HTH_1

PRC2_HTH_1: pfam18118 (158 - 261)

SANT

SANT: cd00167 (432 - 473)

SET

SET: cl34524 (462 - 726)

SET_EZH1

SET_EZH1: cd19217 (607 - 742)

  • 0
  • 200
  • 400
  • 600
  • 747 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase EZH1

enhancer of zeste homolog 1

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109108A Valemetostat tosylate Inhibitor 98.14% Unkown
HY-109108 Valemetostat Inhibitor 99.65% Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-145602 Tulmimetostat Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15646 UNC1999 Inhibitor 99.83% Unkown
HY-144881 (S)-HH2853 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ezh1 NCBI NCBI:2145