Sirt4 - sirtuin 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 304539

Summary

Predicted to enable NAD+ ADP-ribosyltransferase activity; NAD-dependent protein deacetylase activity; and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in cellular response to hypoxia; negative regulation of cardiac muscle cell apoptotic process; and negative regulation of protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Biomarker of non-alcoholic fatty liver disease. Orthologous to human SIRT4 (Sirtuin 4). [provided by Alliance of Genome Resources, Apr 2022]

Sirt4 Products (1)

mRNA Protein Name
NM_001107147.2 NP_001100617.2 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
24029877 RGD
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
24029877 RGD
involved in negative regulation of protein processing involved in protein targeting to mitochondrion IMP
IMP: Inferred from mutant phenotype
24029877 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

  • NAD-dependent ADP-ribosyltransferase sirtuin-4

  • NAD-dependent protein deacetylase sirtuin-4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163316 SIRT4-IN-1 Inhibitor 99.94% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt4 NCBI NCBI:23409