SIRT4 - sirtuin 4 Gene

Also Known as SIR2L4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23409

About SIRT4

Cytogenetic location: 12q24.23-q24.31 Genomic coordinates (GRCh38): 12:120,291,780-120,313,249 (from NCBI)

This gene has 3 transcripts (splice variants), 193 orthologues and 6 paralogues. Broad expression in testis (RPKM 2.4), kidney (RPKM 1.1) and 24 other tissues.

Summary

This gene encodes a member of the Sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast Sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the Sirtuin family. [provided by RefSeq, Jul 2008]

SIRT4 Products (4)

mRNA Protein Name
NM_001385733.1 NP_001372662.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform 1
NM_001385734.1 NP_001372663.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform 2
NM_001385735.1 NP_001372664.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform 2
NM_012240.3 NP_036372.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
16959573 GOA
enables NAD-dependent protein biotinidase activity IDA
IDA: Inferred from direct assay
25525879 GOA
enables NAD-dependent protein lipoamidase activity IDA
IDA: Inferred from direct assay
25525879 GOA
NOT enables NAD-dependent protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
17715127 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16959573 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
24043310 GOA
involved in negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
17715127 GOA
involved in regulation of pyruvate dehydrogenase activity IDA
IDA: Inferred from direct assay
25525879 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
16959573 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
16079181 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRT4 Protein Structure

SIR2

SIR2: Sir2 family (62 - 267)

  • 0
  • 100
  • 200
  • 300
  • 314 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

  • NAD-dependent ADP-ribosyltransferase sirtuin-4

SIRT4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SIRT4 Q9Y6E7 DLAT Homo sapiens P10515
Lipid Cleavage
25525879
Intra
SIRT4 Q9Y6E7 DLAT Homo sapiens P10515
Anti Tag CoIP
25525879
Intra
SIRT4 Q9Y6E7 SLC25A5 Homo sapiens P05141
Anti Tag CoIP
17715127
Intra
SIRT4 Q9Y6E7 PDHX Homo sapiens O00330
Confocal
25525879
Intra
SIRT4 Q9Y6E7 PDHX Homo sapiens O00330
Lipid Cleavage
25525879
Intra
SIRT4 Q9Y6E7 PDHX Homo sapiens O00330
Anti Tag CoIP
25525879
Cross: Cross-species interaction Intra: Intraspecies interaction

SIRT4 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P84903 SIRT4 Antibody (YA4600) ICC/IF, FC, ELISA Human
HY-P84903A SIRT4 Antibody (YA4600)(PBS only) ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Hyperinsulinism

  • Hyperinsulinemia
Monckeberg Arteriosclerosis

  • Monckeberg Medial Calcific Sclerosis
Mitochondrial Complex I Deficiency, Nuclear Type 1

  • Mitochondrial Complex I Deficiency

  • Nadh:Q(1) Oxidoreductase Deficiency

  • MC1DN1

  • Nadh-Coenzyme Q Reductase Deficiency

  • Isolated Mitochondrial Respiratory Chain Complex I Deficiency

  • Isolated Nadh-Coenzyme Q Reductase Deficiency

  • Isolated Nadh-Coq Reductase Deficiency

  • Isolated Nadh-Ubiquinone Reductase Deficiency

  • Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

  • Nuclear Type Mitochondrial Complex I Deficiency 1

  • Isolated Complex I Deficiency

  • Complex 1 Mitochondrial Respiratory Chain Deficiency

  • Nadh Coenzyme Q Reductase Deficiency

  • Complex I Mitochondrial Respiratory Chain Deficiency

  • Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

  • Nadh:Ubiquinone Oxidoreductase Deficiency

  • Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-163316 SIRT4-IN-1 Inhibitor 99.94% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SIRT4 MGD MGI:1922637
Rattus norvegicus SIRT4 RGD RGD:1310413
Canis familiaris SIRT4 VGNC VGNC:46185
Macaca mulatta SIRT4 VGNC VGNC:100105
Felis catus SIRT4 VGNC VGNC:65158
Bos taurus SIRT4 VGNC VGNC:34633
Others SIRT4 NCBI