2. Gene
  3. Atf6 - activating transcription factor 6 Gene

Atf6 - activating transcription factor 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 304962 | Gene type: protein coding

About Atf6

Primary_assembly 13: 82,930,034-83,107,177 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 218 orthologues, 10 paralogues and is associated with 15 phenotypes. Biased expression in Kidney (RPKM 188.3), Liver (RPKM 159.4) and 9 other tissues.

Summary

Enables ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including endoplasmic reticulum unfolded protein response; positive regulation of ATF6-mediated unfolded protein response; and positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress. Predicted to act upstream of or within positive regulation of Autophagy and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Biomarker of borna disease. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Atf6 Products(1)

mRNA Protein Name
NM_001107196.1 NP_001100666.1 cyclic AMP-dependent transcription factor ATF-6 alpha

Atf6 Protein Structure

bZIP_ATF6

bZIP_ATF6: cd14700 (295 - 346)

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  • 656 a.a.
Protein Preferred Names Protein Names

cyclic AMP-dependent transcription factor ATF-6 alpha

ATF6-alpha

activating transcription factor 6 alpha

cAMP-dependent transcription factor ATF-6 alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108434 Ceapin-A7 99.15% Unkown
HY-124293 AA147 Activator 99.89% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atf6 NCBI NCBI:22926