Atf6 - activating transcription factor 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 304962

About Atf6

Primary_assembly 13: 82,930,034-83,107,177 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 218 orthologues, 10 paralogues and is associated with 15 phenotypes. Biased expression in Kidney (RPKM 188.3), Liver (RPKM 159.4) and 9 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Predicted to be involved in several processes, including endoplasmic reticulum unfolded protein response; positive regulation of ATF6-mediated unfolded protein response; and positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress. Predicted to act upstream of or within positive regulation of Autophagy and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Biomarker of borna disease. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Atf6 Products (1)

mRNA Protein Name
NM_001107196.1 NP_001100666.1 cyclic AMP-dependent transcription factor ATF-6 alpha

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22682248 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Atf6 Protein Structure

bZIP_ATF6

bZIP_ATF6: cd14700 (295 - 346)

  • 0
  • 200
  • 400
  • 600
  • 656 a.a.
Protein Preferred Names Protein Names

cyclic AMP-dependent transcription factor ATF-6 alpha

  • ATF6-alpha

  • activating transcription factor 6 alpha

  • cAMP-dependent transcription factor ATF-6 alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108434 Ceapin-A7 99.95% Unkown
HY-124293 AA147 Activator 99.81% Unkown
HY-W050044 L-Azetidine-2-carboxylic acid 99.97% Unkown
HY-101484A NE-100 hydrochloride Activator 99.1% Unkown
HY-132182 HPA-12 Activator 99.40% Unkown
HY-123581 Quinocetone Activator 98.25% Unkown
HY-158104 LPPM-8 Inhibitor / Unkown
HY-123581R Quinocetone (Standard) Activator 97.94% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atf6 NCBI NCBI:22926