ACAT2 - acetyl-CoA acetyltransferase 2 Gene

Also Known as Acat3; Ab2-076

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 308100

About ACAT2

Primary_assembly 1: 47,695,788-47,752,821 forward strand.mRatBN7.2:CM026974.1

This gene has 5 transcripts (splice variants), 213 orthologues, 7 paralogues and is associated with 7 phenotypes. Biased expression in Liver (RPKM 12.4), Brain (RPKM 14.9) and 9 other tissues.

Summary

Enables acetyl-CoA C-acetyltransferase activity. Involved in several processes, including bile acid signaling pathway; ketone body catabolic process; and liver development. Located in cytosol. Biomarker of premature menopause. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

ACAT2 Products (1)

mRNA Protein Name
NM_001006995.1 NP_001006996.1 acetyl-CoA acetyltransferase, cytosolic

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables acetyl-CoA C-acetyltransferase activity IDA
IDA: Inferred from direct assay
10806397 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
11786296 RGD
involved in cellular response to nutrient IEP
IEP: Inferred from expression pattern
12563020 RGD
involved in ketone body catabolic process IEP
IEP: Inferred from expression pattern
5116556 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
5166591 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACAT2 Protein Structure

PRK05790

PRK05790: PRK05790 (7 - 395)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
Protein Preferred Names Protein Names

acetyl-CoA acetyltransferase, cytosolic

  • acetyl-Coenzyme A acetyltransferase 2

  • acetyl-Coenzyme A acetyltransferase 3

  • cytosolic acetoacetyl-CoA thiolase

Recombinant ACAT2 Proteins

Cat. No. Product Name Accession Purity
HY-P75543 ACAT2 Protein, Rat (His) Q5XI22 (M1-G397) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-13215 Avasimibe Inhibitor 99.85% Phase 3
HY-100401 Pactimibe Inhibitor 99.98% Phase 3
HY-100400A K-604 dihydrochloride Inhibitor 99.42% Phase 2
HY-100399A Nevanimibe hydrochloride Inhibitor 99.49% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100399 Nevanimibe Inhibitor 98.99% Yes
HY-100401A Pactimibe sulfate Inhibitor 98.0% Unkown
HY-N18066 Esculeogenin A Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ACAT2 NCBI NCBI:39