Pak5 - p21 (RAC1) activated kinase 5 Gene

Rattus norvegicus

Also known as Pak7; PAK-5; PAK-7

Gene ID: 311450 | Gene type: protein coding

About Pak5

Primary_assembly 3: 123,396,497-123,703,930 reverse strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 214 orthologues, 36 paralogues and is associated with 3 phenotypes. Restricted expression toward (RPKM 12.5).

Summary

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; protein phosphorylation; and regulation of MAPK cascade. Predicted to act upstream of or within learning or memory; locomotory behavior; and negative regulation of extrinsic apoptotic signaling pathway. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in cytoplasm and synapse. Orthologous to human PAK5 (p21 (RAC1) activated kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Pak5 Products(1)

mRNA	Protein	Name
NM_001107781.1	NP_001101251.1	serine/threonine-protein kinase PAK 5

Pak5 Protein Structure

CRIB_PAK_like

STKc_PAK5

0
200
400
600
718 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PAK 5

p21 (CDKN1A)-activated kinase 7	p21 (RAC1) activated kinase 7
p21 protein (Cdc42/Rac)-activated kinase 7	p21-activated kinase 5
p21-activated kinase 7	serine/threonine-protein kinase PAK 7

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15323	PRT062607 Hydrochloride	Inhibitor	98.68%	Phase 2
HY-13007	PF-3758309	Inhibitor	99.84%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15324	PRT062607 acetate	Inhibitor	99.83%	Unkown
HY-13007B	PF-3758309 dihydrochloride	Inhibitor	/	Unkown
HY-13007A	PF-3758309 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pak5	NCBI	NCBI:57144

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