NANOS1 - nanos C2HC-type zinc finger 1 Gene

Also Known as NOS1; NOS-1; SPGF12; EC_Rep1a; ZC2HC12A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 340719

About NANOS1

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,029,714-119,033,730 (from NCBI)

This gene has 2 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 3 phenotypes.

Summary

This gene encodes a CCHC-type Zinc Finger Protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]

NANOS1 Products (1)

mRNA Protein Name
NM_199461.4 NP_955631.1 nanos homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme activator activity IDA
IDA: Inferred from direct assay
24736845 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17047063 GOA
Biological Process GO Annotation Evidence References Source
involved in cell migration IDA
IDA: Inferred from direct assay
18223680 GOA
involved in epithelial cell migration IDA
IDA: Inferred from direct assay
17047063 GOA
involved in mRNA destabilization IDA
IDA: Inferred from direct assay
24736845 GOA
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
24736845 GOA
acts upstream of or within post-transcriptional regulation of gene expression IDA
IDA: Inferred from direct assay
25100735 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12690449 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17047063 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NANOS1 Protein Structure

zf-nanos

zf-nanos: Nanos RNA binding domain (214 - 267)

  • 0
  • 100
  • 200
  • 292 a.a.
Protein Preferred Names Protein Names

nanos homolog 1

NANOS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NANOS1 Q8WY41 CTNND1 Homo sapiens O60716-21
Anti Bait CoIP
17047063
Cross: Cross-species interaction Intra: Intraspecies interaction

NANOS1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811223 Nanos 1 Antibody WB, IHC-P Human, Mouse

Related Diseases

Diseases Alias
Spermatogenic Failure 12

  • SPGF12
Male Infertility With Teratozoospermia Due To Single Gene Mutation
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Infertility
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Spermatogenic Failure 10

  • SPGF10

  • Spermatogenic Failure With Defective Sperm Annulus
Oligoasthenoteratozoospermia

  • Oat

  • Oligoasthenoteratospermia
Testis Seminoma

  • Seminoma Of Testis

  • Seminoma Testis

  • Testicular Seminoma Pure

  • Seminoma
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Multiple Synostoses Syndrome

  • Symphalangism-Brachydactyly Syndrome

  • Deafness-Hermann Type Symphalangism Syndrome

  • Facio-Audio-Symphalangism

  • Hearing Loss-Hermann Type Symphalangism Syndrome

  • Wl Syndrome

  • Multiple Synostosis Syndrome
Cerebrooculofacioskeletal Syndrome 2

  • COFS2

  • Cerebro-Oculo-Facio-Skeletal Syndrome 2

  • Cofs Syndrome
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09021 NANOS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21891 Nanos1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28408 Nanos1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NANOS1 MGD MGI:2669254
Rattus norvegicus NANOS1 RGD RGD:1308194
Bos taurus NANOS1 VGNC VGNC:106833
Macaca mulatta NANOS1 VGNC VGNC:106078
Others NANOS1 NCBI