Ppm1e - protein phosphatase, Mg2+/Mn2+ dependent, 1E Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360593

Summary

Enables protein serine/threonine Phosphatase activity. Predicted to be involved in several processes, including negative regulation of protein kinase activity; peptidyl-threonine dephosphorylation; and positive regulation of stress fiber assembly. Located in mitochondrion and nucleus. Orthologous to human PPM1E (protein Phosphatase, Mg2+/Mn2+ dependent 1E). [provided by Alliance of Genome Resources, Apr 2022]

Ppm1e Products (1)

mRNA Protein Name
NM_198773.1 NP_942068.1 protein phosphatase 1E

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15680915 RGD
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
11726284 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11726284 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein phosphatase 1E

  • ca(2+)/calmodulin-dependent protein kinase phosphatase N

  • caMKN

  • caMKP-N

  • caMKP-nucleus

  • calmodulin-dependent protein kinase phosphatase N

  • partner of PIX 1

  • partner of PIX-alpha

  • partner of PIXA

  • protein phosphatase 1E (PP2C domain containing)

Ppm1e Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ppm1e Q80Z30 Gapdh Rattus norvegicus P04797
Anti Bait CoIP
15680915
Intra
Ppm1e Q80Z30 Gapdh Rattus norvegicus P04797
Far-WB
15680915
Intra
Ppm1e Q80Z30 Aldoa Rattus norvegicus P05065
Far-WB
15680915
Intra
Ppm1e Q80Z30 Aldoa Rattus norvegicus P05065
FPS
15680915
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10963 PPM1E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21029 Ppm1e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27546 Ppm1e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppm1e NCBI NCBI:22843