Tlr3 - toll-like receptor 3 Gene
Species: Rattus norvegicus
About Tlr3
This gene has 2 transcripts (splice variants), 156 orthologues, 26 paralogues and is associated with 46 phenotypes. Biased expression in Adrenal (RPKM 17.4), Kidney (RPKM 158.8) and 9 other tissues.
Summary
Enables double-stranded RNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to exogenous dsRNA; and microglial cell activation. Located in cell surface. Used to study asthma. Biomarker of colitis; pancreatitis; perinatal necrotizing enterocolitis; peripheral nervous system disease; and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and type 1 diabetes mellitus. Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Tlr3 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_198791.2 | NP_942086.2 | toll-like receptor 3 precursor |
Tlr3 Protein Structure
LRR_RI: sd00033 (36 - 52)
LRR_RI: sd00033 (53 - 76)
PLN00113: cl33413 (65 - 645)
LRR_RI: sd00033 (77 - 100)
LRR_RI: sd00033 (101 - 124)
LRR_RI: sd00033 (125 - 148)
LRR_RI: sd00033 (149 - 198)
LRR_RI: sd00033 (199 - 249)
LRR_RI: sd00033 (250 - 275)
LRR_RI: sd00033 (276 - 299)
LRR_RI: sd00033 (300 - 321)
LRR_RI: sd00033 (324 - 380)
LRR_RI: sd00033 (381 - 406)
LRR_RI: sd00033 (409 - 432)
LRR_RI: sd00033 (433 - 457)
LRR_RI: sd00033 (458 - 481)
LRR_RI: sd00033 (482 - 507)
LRR_RI: sd00033 (508 - 531)
LRR_RI: sd00033 (532 - 563)
LRR_RI: sd00033 (564 - 585)
LRR_RI: sd00033 (588 - 611)
LRR_RI: sd00033 (612 - 630)
LRRCT: smart00082 (645 - 697)
Tlr3_TMD: pfam17968 (698 - 730)
TIR: smart00255 (755 - 900)
- 0
- 200
- 400
- 600
- 800
- 905 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
toll-like receptor 3 |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-135748 | Polyinosinic-polycytidylic acid sodium | Agonist | 99.40% | Unkown |
| HY-108473 | CU-CPT 4a | Inhibitor | 99.50% | Unkown |
| HY-18325 | AN-3485 | Inhibitor | 97.38% | Unkown |
| HY-135748A | Poly (I:C):Kanamycin (1:1) sodium | Agonist | 99.0% | Unkown |
| HY-101929 | CU-CPT17e | Agonist | 98.67% | Unkown |
| HY-114592 | M199 | Inhibitor | 98.55% | Unkown |
| HY-176192 | SMU-14a | Inhibitor | / | Unkown |
| HY-134958 | Polyinosinic-polycytidylic acid potassium | Agonist | / | Unkown |
| HY-183313 | IAV-IN-5 | Inhibitor | / | Unkown |
| HY-183079 | ENDO12 | Inhibitor | / | Unkown |
| HY-165632 | Creatine ethyl ester | Activator | / | Unkown |
| HY-W682115 | Poly(C) | Activator | / | Unkown |
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