Tlr3 - toll-like receptor 3 Gene

Rattus norvegicus

Gene ID: 364594 | Gene type: protein coding

About Tlr3

Primary_assembly 16: 46,822,039-46,836,545 forward strand.mRatBN7.2:CM026989.1

This gene has 2 transcripts (splice variants), 156 orthologues, 26 paralogues and is associated with 46 phenotypes. Biased expression in Adrenal (RPKM 17.4), Kidney (RPKM 158.8) and 9 other tissues.

Summary

Enables double-stranded RNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to exogenous dsRNA; and microglial cell activation. Located in cell surface. Used to study asthma. Biomarker of colitis; pancreatitis; perinatal necrotizing enterocolitis; peripheral nervous system disease; and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and type 1 diabetes mellitus. Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tlr3 Products(1)

mRNA	Protein	Name
NM_198791.2	NP_942086.2	toll-like receptor 3 precursor

Tlr3 Protein Structure

LRR_RI

PLN00113

LRR_RI

LRRCT

Tlr3_TMD

TIR

0
200
400
600
800
905 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108473	CU-CPT 4a	Inhibitor	98.91%	Unkown
HY-135748	Polyinosinic-polycytidylic acid sodium	Agonist	99.4%	Unkown
HY-101929	CU-CPT17e	Agonist	99.00%	Unkown
HY-18325	AN-3485	Inhibitor	95.63%	Unkown
HY-134958	Polyinosinic-polycytidylic acid potassium	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlr3	NCBI	NCBI:7098
Macaca fascicularis	Tlr3	NCBI	NCBI:102138517
Mus musculus	Tlr3	NCBI	NCBI:142980

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