Lpar5 - lysophosphatidic acid receptor 5 Gene

Also Known as LPA5; GPR93; Gpr92; Gm1072

Species: Mus musculus

Gene Type: protein coding
Gene ID: 381810

About Lpar5

Chromosome 6: 125,044,883-125,059,435 forward strand.GRCm39:CM000999.3

This gene has 2 transcripts (splice variants), 252 orthologues, 1 paralogue and is associated with 11 phenotypes. Biased expression in small intestine adult (RPKM 19.8), duodenum adult (RPKM 18.6) and 7 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Acts upstream of or within behavioral response to pain and positive regulation of CREB transcription factor activity. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including future brain; gut; immune system; liver; and nervous system. Orthologous to human LPAR5 (lysophosphatidic acid receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Lpar5 Products (2)

mRNA Protein Name
NM_001163269.2 NP_001156741.2 lysophosphatidic acid receptor 5
NM_001163268.2 NP_001156740.2 lysophosphatidic acid receptor 5

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral response to pain IMP
IMP: Inferred from mutant phenotype
22461625 MGI
acts upstream of or within positive regulation of CREB transcription factor activity IMP
IMP: Inferred from mutant phenotype
22461625 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lpar5 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (26 - 311)

7tm_GPCRs

7tm_GPCRs: cd14964 (28 - 52)

7tm_GPCRs

7tm_GPCRs: cd14964 (61 - 82)

7tm_GPCRs

7tm_GPCRs: cd14964 (98 - 120)

7tm_GPCRs

7tm_GPCRs: cd14964 (143 - 159)

7tm_GPCRs

7tm_GPCRs: cd14964 (192 - 215)

7tm_GPCRs

7tm_GPCRs: cd14964 (236 - 258)

7tm_GPCRs

7tm_GPCRs: cd14964 (279 - 304)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
Protein Preferred Names Protein Names

lysophosphatidic acid receptor 5

  • G protein-coupled receptor 92

  • LPA receptor 5

  • LPA-5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114379 AS2717638 Antagonist 99.85% Unkown
HY-15706 H2L 5765834 Antagonist 98.66% Unkown
HY-W040176 N-PTyrosine PA ammonium Modulator / Unkown
HY-148291 BrP-LPA sodium Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lpar5 NCBI NCBI:57121