Taok2 - TAO kinase 2 Gene

Also Known as PSK; PSK1; TAO1; TAO2; MAP3K17; mKIAA0881; B230344N16; 1110033K02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 381921

Summary

Enables neuropilin binding activity. Involved in neuron projection morphogenesis; positive regulation of JNK cascade; and regulation of actin Cytoskeleton organization. Located in axonal growth cone and dendritic growth cone. Colocalizes with actin Cytoskeleton. Is expressed in central nervous system and retina. Orthologous to human TAOK2 (TAO kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Taok2 Products (2)

mRNA Protein Name
NM_001163774.2 NP_001157246.1 serine/threonine-protein kinase TAO2 isoform 1
NM_001163775.2 NP_001157247.1 serine/threonine-protein kinase TAO2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neuropilin binding IPI
IPI: Inferred from physical interaction
22683681 MGI
Biological Process GO Annotation Evidence References Source
involved in axonogenesis IGI
IGI: Inferred from genetic interaction
22683681 MGI
involved in axonogenesis IMP
IMP: Inferred from mutant phenotype
22683681 MGI
involved in basal dendrite arborization IDA
IDA: Inferred from direct assay
22683681 MGI
involved in basal dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
22683681 MGI
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
22683681 MGI
involved in regulation of actin cytoskeleton organization IDA
IDA: Inferred from direct assay
22683681 MGI
Cellular Component GO Annotation Evidence References Source
colocalizes with actin cytoskeleton IDA
IDA: Inferred from direct assay
22683681 MGI
located in axon IDA
IDA: Inferred from direct assay
22683681 MGI
located in axonal growth cone IDA
IDA: Inferred from direct assay
22683681 MGI
located in dendritic growth cone IDA
IDA: Inferred from direct assay
22683681 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
22683681 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase TAO2

  • TAO kinase 2TAO kinase 2

  • thousand and one amino acid protein 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15141 Staurosporine 99.77% Phase 4
HY-100491 H3B-6527 Inhibitor 98.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122232 SW083688 99.78% Unkown
HY-181280 VU6083859 Inhibitor / Unkown
HY-181281 VU6080195 Activator / Unkown
HY-RS14199 TAOK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181619 TAO Kinase-IN-3 Inhibitor / Unkown
HY-RS20110 Taok2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26614 Taok2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Taok2 NCBI NCBI:9344