KLRD1 - killer cell lectin like receptor D1 Gene

Also Known as CD94

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3824

About KLRD1

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,238,961-10,329,608 (from NCBI)

This gene has 11 transcripts (splice variants), 394 orthologues and 23 paralogues. Broad expression in spleen (RPKM 3.3), lung (RPKM 0.9) and 15 other tissues.

Summary

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

KLRD1 Products (8)

mRNA Protein Name
NM_001114396.3 NP_001107868.2 natural killer cells antigen CD94 isoform 1
NM_001351060.2 NP_001337989.1 natural killer cells antigen CD94 isoform 3
NM_001351062.2 NP_001337991.1 natural killer cells antigen CD94 isoform 1
NM_001351063.2 NP_001337992.1 natural killer cells antigen CD94 isoform 4
NM_001414224.1 NP_001401153.1 natural killer cells antigen CD94 isoform 5
NM_001414225.1 NP_001401154.1 natural killer cells antigen CD94 isoform 6
NM_002262.5 NP_002253.2 natural killer cells antigen CD94 isoform 1
NM_007334.3 NP_031360.1 natural killer cells antigen CD94 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables HLA-E specific inhibitory MHC class Ib receptor activity IDA
IDA: Inferred from direct assay
9486650 GOA
enables MHC class I protein complex binding IPI
IPI: Inferred from physical interaction
18448674 GOA
enables MHC class Ib protein binding, via antigen binding groove IPI
IPI: Inferred from physical interaction
25631937 GOA
enables protein antigen binding IDA
IDA: Inferred from direct assay
18448674 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8046333 GOA
Biological Process GO Annotation Evidence References Source
involved in natural killer cell mediated immunity IDA
IDA: Inferred from direct assay
18448674 GOA
involved in negative regulation of T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
9485206 GOA
involved in negative regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
9486650 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
9754572 GOA
involved in stimulatory C-type lectin receptor signaling pathway IDA
IDA: Inferred from direct assay
9655483 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
9485206 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
18448674 GOA
part of receptor complex IPI
IPI: Inferred from physical interaction
18448674 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLRD1 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (78 - 175)

  • 0
  • 100
  • 179 a.a.
Protein Preferred Names Protein Names

natural killer cells antigen CD94

  • CD94 antigen

KLRD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLRD1 Q13241 KLRC2 Homo sapiens P26717
SPR
18083576
Intra
KLRD1 Q13241 KLRC1 Homo sapiens P26715
X-Ray Diffraction
18083576
Intra
KLRD1 Q13241 KLRC1 Homo sapiens P26715
SPR
18083576
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLRD1 Proteins

Cat. No. Product Name Accession Purity
HY-P70713 NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Flag) P26715 (R100-L233)&Q13241-1 (S34-I179) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72700 CD94 Protein, Human (HEK293, His) Q13241-1 (S34-I179) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77803 NKG2A-CD94 Heterodimer Protein, Human (HEK293, Fc-Flag) P26715 (R100-L233)&Q13241-1 (S34-I179) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77804 NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc) P26715 (R100-L233)&Q13241-1 (S34-I179) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77805 NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Avi) P26715 (R100-L233)&Q13241-1 (S34-I179) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77806 NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) P26715 (R100-L233)&Q13241-1 (S34-I179) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77807 NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi) P26717 (E98-L231)&Q13241-1 (S34-I179) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78097 CD94 Protein, Human (Biotinylated, HEK293, His-Avi) Q13241-1 (S34-I179) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78421 CD94 Protein, Human (HEK293, His-Avi) Q13241-1 (S34-I179) ≥ 95%, as determined by Bis-Tris PAGE.

KLRD1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85012 CD94 Antibody (YA4704) ELISA, FC Human
HY-P85095 CD94 Antibody (YA4787) WB, FC, ELISA Human

Related Diseases

Diseases Alias
Nk Cell Deficiency
Chronic Nk-Cell Lymphocytosis

  • Nk-Cell Large Granular Lymphocyte Lymphocytosis

  • Chronic Lymphoproliferative Disorder Of Nk-Cells
Human Cytomegalovirus Infection

  • Cytomegalovirus Infection

  • Cytomegalovirus Infections
Aggressive Nk-Cell Leukemia

  • Aggressive Nk-Cell Leukaemia

  • Large Granular Lymphocyte Leukemia, Nk-Cell Type

  • Natural Killer Cell Leukaemia

  • Natural Killer Cell Leukemia

  • Aggressive Nk Cell Leukemia

  • Ankl

  • Aggressive Natural Killer Cell Leukemia

  • Ankcl

  • Aggressive Nk-Cell Lymphoma

  • Nk-Cell Lgl Leukemia

  • Nk-Cell Large Granular Lymphocyte Leukemia

  • Abnormality Of The Ankles

  • Aggressive Natural Killer-Cell Leukemia

  • Leukemia, Large Granular Lymphocytic

  • Leukemia, Natural Killer Cell Large Granular Lymphocytic
Psoriasis
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Ceftazidime Allergy

  • Fortaz Allergy

  • Tazicef Allergy
Parotid Gland Adenoid Cystic Carcinoma

  • Adenoid Cystic Carcinoma Of Parotid Gland
Human Immunodeficiency Virus Infectious Disease

  • Hiv Infections
Bare Lymphocyte Syndrome, Type I

  • Hla Class I Deficiency

  • Mhc Class I Deficiency

  • Bls, Type I

  • Bare Lymphocyte Syndrome Type I

  • Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

  • Blsi

  • Mhc Class 1 Deficiency

  • Major Histocompatibility Complex Class 1 Deficiency

  • Bare Lymphocyte Syndrome 1

  • BLS1

  • Bls I

  • Bls Type I

  • Bl-1

  • Bare Lymphocyte Syndrome Type 1

  • Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

  • Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

  • Bls - [Bare Lymphocyte Syndrome] Nos
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07395 KLRD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19212 Klrd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25701 Klrd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KLRD1 VGNC VGNC:42486
Macaca mulatta KLRD1 VGNC VGNC:100068
Mus musculus KLRD1 MGD MGI:1196275
Rattus norvegicus KLRD1 RGD RGD:2978
Others KLRD1 NCBI