2. Gene
  3. KLRD1 - killer cell lectin like receptor D1 Gene

KLRD1 - killer cell lectin like receptor D1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CD94

Gene ID: 3824 | Gene type: protein coding

About KLRD1

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,238,961-10,329,608 (from NCBI)

This gene has 11 transcripts (splice variants), 394 orthologues and 23 paralogues. Broad expression in spleen (RPKM 3.3), lung (RPKM 0.9) and 15 other tissues.

Summary

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

KLRD1 Products(8)

mRNA Protein Name
NM_001114396.3 NP_001107868.2 natural killer cells antigen CD94 isoform 1
NM_001351060.2 NP_001337989.1 natural killer cells antigen CD94 isoform 3
NM_001351062.2 NP_001337991.1 natural killer cells antigen CD94 isoform 1
NM_001351063.2 NP_001337992.1 natural killer cells antigen CD94 isoform 4
NM_001414224.1 NP_001401153.1 natural killer cells antigen CD94 isoform 5
NM_001414225.1 NP_001401154.1 natural killer cells antigen CD94 isoform 6
NM_002262.5 NP_002253.2 natural killer cells antigen CD94 isoform 1
NM_007334.3 NP_031360.1 natural killer cells antigen CD94 isoform 2

KLRD1 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (78 - 175)

  • 0
  • 100
  • 179 a.a.
Protein Preferred Names Protein Names

natural killer cells antigen CD94

CD94 antigen

Recombinant KLRD1 Proteins

Cat. No. Product Name Accession Purity
HY-P70713 NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Flag) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P72700 CD94 Protein, Human (HEK293, His) Q13241 (S34-I179) ≥95%
HY-P77803 NKG2A-CD94 Heterodimer Protein, Human (HEK293, Fc-Flag) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P77804 NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P77805 NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Avi) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P77806 NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P77807 NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi) P26717 (E98-L231)&Q13241 (S34-I179) ≥95%
HY-P78097 CD94 Protein, Human (Biotinylated, HEK293, His-Avi) Q13241 (S34-I179) ≥95%
HY-P78421 CD94 Protein, Human (HEK293, His-Avi) Q13241 (S34-I179) ≥95%

Related Diseases

Diseases Alias
Nk Cell Deficiency
Chronic Nk-Cell Lymphocytosis

Nk-Cell Large Granular Lymphocyte Lymphocytosis

Chronic Lymphoproliferative Disorder Of Nk-Cells
Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections
Aggressive Nk-Cell Leukemia

Aggressive Nk-Cell Leukaemia

Large Granular Lymphocyte Leukemia, Nk-Cell Type

Natural Killer Cell Leukaemia

Natural Killer Cell Leukemia

Aggressive Nk Cell Leukemia

Ankl

Aggressive Natural Killer Cell Leukemia

Ankcl

Aggressive Nk-Cell Lymphoma

Nk-Cell Lgl Leukemia

Nk-Cell Large Granular Lymphocyte Leukemia

Abnormality Of The Ankles

Aggressive Natural Killer-Cell Leukemia

Leukemia, Large Granular Lymphocytic

Leukemia, Natural Killer Cell Large Granular Lymphocytic
Psoriasis
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy
Parotid Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Parotid Gland
Human Immunodeficiency Virus Infectious Disease

Hiv Infections
Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency

Mhc Class I Deficiency

Bls, Type I

Bare Lymphocyte Syndrome Type I

Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

Blsi

Mhc Class 1 Deficiency

Major Histocompatibility Complex Class 1 Deficiency

Bare Lymphocyte Syndrome 1

BLS1

Bls I

Bls Type I

Bl-1

Bare Lymphocyte Syndrome Type 1

Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

Bls - [Bare Lymphocyte Syndrome] Nos
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07395 KLRD1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KLRD1 VGNC VGNC:42486
Macaca mulatta KLRD1 VGNC VGNC:100068
Mus musculus KLRD1 MGD MGI:1196275
Rattus norvegicus KLRD1 RGD RGD:2978
Others KLRD1 NCBI