KPNB1 - karyopherin subunit beta 1 Gene

Also Known as IMB1; IPO1; IPOB; Impnb; NTF97

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3837

About KPNB1

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,649,919-47,685,505 (from NCBI)

This gene has 16 transcripts (splice variants), 215 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 74.8), appendix (RPKM 47.4) and 25 other tissues.

Summary

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

KPNB1 Products (2)

mRNA	Protein	Name
NM_001276453.2	NP_001263382.1	importin subunit beta-1 isoform 2
NM_002265.6	NP_002256.2	importin subunit beta-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	22701565	GOA
enables nuclear import signal receptor activity	IDA IDA: Inferred from direct assay	14645851	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9405152	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11984006	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in NLS-bearing protein import into nucleus	IDA IDA: Inferred from direct assay	14645851	GOA
involved in RNA import into nucleus	IDA IDA: Inferred from direct assay	9670026	GOA
involved in astral microtubule organization	IMP IMP: Inferred from mutant phenotype	23783028	GOA
involved in establishment of mitotic spindle localization	IMP IMP: Inferred from mutant phenotype	23783028	GOA
involved in mitotic chromosome movement towards spindle pole	IMP IMP: Inferred from mutant phenotype	23783028	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	23783028	GOA
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	23783028	GOA
acts upstream of or within protein import into nucleus	IDA IDA: Inferred from direct assay	15964792	GOA
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	7615630	GOA
involved in protein import into nucleus	IMP IMP: Inferred from mutant phenotype	17209048	GOA
involved in ribosomal protein import into nucleus	IDA IDA: Inferred from direct assay	9687515	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NLS-dependent protein nuclear import complex	IPI IPI: Inferred from physical interaction	10353244	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	11891849	GOA
located in endoplasmic reticulum tubular network	IDA IDA: Inferred from direct assay	22701565	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	22701565	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	9670026	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KPNB1 Protein Structure

IBN_N

HEAT_EZ

0
200
400
600
800
876 a.a.

Protein Preferred Names	Protein Names
importin subunit beta-1	PTAC97

KPNB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KPNB1	Q14974	P2RY6	Homo sapiens	Q15077	Pull Down	30833792
Intra	KPNB1	Q14974	SMNDC1	Homo sapiens	O75940	Pull Down	15494309
Cross	KPNB1	Q14974	NSP1	Saccharomyces cerevisiae	P14907	X-Ray Diffraction	12372823
Cross	KPNB1	Q14974	NSP1	Saccharomyces cerevisiae	P14907	Competition Binding	19680228
Intra	KPNB1	Q14974	KPNA7	Homo sapiens	A9QM74	Pull Down	20701745
Intra	KPNB1	Q14974	SLC15A3	Homo sapiens	F5H1C8	Pull Down	30833792
Intra	KPNB1	Q14974	CD74	Homo sapiens	P04233	Pull Down	30833792
Intra	KPNB1	Q14974	NUP153	Homo sapiens	P49790	Phage Display	35044719
Intra	KPNB1	Q14974	NUP153	Homo sapiens	P49790	Anti Tag CoIP	35271311
Intra	KPNB1	Q14974	NUP153	Homo sapiens	P49790	FPS	35044719
Intra	KPNB1	Q14974	NUP153	Homo sapiens	P49790	Anti Tag CoIP	26496610
Intra	KPNB1	Q14974	KPNA2	Homo sapiens	P52292	Anti Tag CoIP	17596301
Intra	KPNB1	Q14974	KPNA2	Homo sapiens	P52292	Anti Tag CoIP	35271311
Intra	KPNB1	Q14974	KPNA2	Homo sapiens	P52292	Affinity Chrom	9405152
Intra	KPNB1	Q14974	KPNA2	Homo sapiens	P52292	Anti Tag CoIP	26496610
Intra	KPNB1	Q14974	KPNA2	Homo sapiens	P52292	Pull Down	20701745
Intra	KPNB1	Q14974	KPNA2	Homo sapiens	P52292	SPR	10523667
Intra	KPNB1	Q14974	MAP3K14	Homo sapiens	Q99558	Pull Down	30833792
Intra	KPNB1	Q14974	KPNA3	Homo sapiens	O00505	Anti Tag CoIP	35271311
Intra	KPNB1	Q14974	KPNA3	Homo sapiens	O00505	SPR	10523667
Intra	KPNB1	Q14974	KPNA3	Homo sapiens	O00505	Anti Tag CoIP	26496610
Intra	KPNB1	Q14974	KPNA1	Homo sapiens	P52294	Anti Tag CoIP	26496610
Intra	KPNB1	Q14974	KPNA1	Homo sapiens	P52294	SPR	10523667
Intra	KPNB1	Q14974	KPNA1	Homo sapiens	P52294	Anti Tag CoIP	35271311
Intra	KPNB1	Q14974	KPNA6	Homo sapiens	O60684	Anti Tag CoIP	26496610
Intra	KPNB1	Q14974	KPNA6	Homo sapiens	O60684	Anti Tag CoIP	35271311
Intra	KPNB1	Q14974	KPNA6	Homo sapiens	O60684	SPR	10523667
Intra	KPNB1	Q14974	SMN1	Homo sapiens	Q16637-3	CoIP	15494309
Intra	KPNB1	Q14974	SMN1	Homo sapiens	Q16637-3	Pull Down	15494309
Intra	KPNB1	Q14974	KPNA4	Homo sapiens	O00629	Anti Tag CoIP	26496610
Intra	KPNB1	Q14974	KPNA4	Homo sapiens	O00629	Anti Tag CoIP	35271311
Intra	KPNB1	Q14974	KPNA4	Homo sapiens	O00629	Pull Down	20818336
Intra	KPNB1	Q14974	KPNA4	Homo sapiens	O00629	SPR	10523667
Intra	KPNB1	Q14974	UNC93B1	Homo sapiens	Q9H1C4	Pull Down	30833792
Intra	KPNB1	Q14974	TNFSF13B	Homo sapiens	Q9Y275	Pull Down	30833792
Intra	KPNB1	Q14974	ERBB2	Homo sapiens	P04626	Anti Bait CoIP	16314522
Cross	KPNB1	Q14974	L2	Human papillomavirus	P03107	Pull Down	15507604
Cross	KPNB1	Q14974	L1	Human papillomavirus	P03101	Pull Down	11971900
Cross	KPNB1	Q14974	L1	Human papillomavirus	P03101	Pull Down	15507604
Cross	KPNB1	Q14974	Mrtfa	Mus musculus	Q8K4J6	Pull Down	20818336
Cross	KPNB1	Q14974	rev	Human immunodeficiency virus	P04620	Affinity Chrom	9405152
Cross	KPNB1	Q14974	rev	Human immunodeficiency virus	P04620	Pull Down	9405152

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KPNB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70837	KPNB1 Protein, Human (His)	Q14974-1 (M1-A876)	≥ 90%, as determined by reducing SDS-PAGE.

KPNB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86934	KPNB1 Antibody (YA6627)	WB, IHC-P, IF-Tissue, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Venezuelan Equine Encephalitis	Venezuelan Equine Fever Venezuelan Equine Encephalomyelitis Encephalitis Venezuelan Equine Encephalomyelitis, Venezuelan Equine Venezuelan Encephalitis Disorder Due To Venezuelan Equine Encephalitis Virus Venezuelan Equine Encephalitis Virus Infection Venezuelan Equine Encephalomyelitis Virus Disease
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Campomelic Dysplasia	Acampomelic Campomelic Dysplasia Camptomelic Dysplasia Campomelic Dysplasia With Autosomal Sex Reversal Cmpd CMD1 Cmpd1 Cmpd1/Sra1 Acampomelic Campomelic Dysplasia With Autosomal Sex Reversal Campomelic Dwarfism Campomelic Syndrome Dysplasia, Campomelic Chronic Myeloproliferative Disorder Familial Dilated Cardiomyopathy
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170316	Ibetazol	Inhibitor	99.80%	Unkown
HY-RS07422	KPNB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18529	Kpnb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25011	Kpnb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KPNB1	VGNC	VGNC:42506
Bos taurus	KPNB1	VGNC	VGNC:30707
Mus musculus	KPNB1	MGD	MGI:107532
Macaca mulatta	KPNB1	VGNC	VGNC:74203
Felis catus	KPNB1	VGNC	VGNC:67979
Rattus norvegicus	KPNB1	RGD	RGD:2909
Others	KPNB1	NCBI