Mrtfa - myocardin related transcription factor A Gene

Also Known as Mal; AMKL; Bsac; Mkl1; Mrtf-A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 223701

Summary

Enables several functions, including DNA-binding transcription factor activity; actin monomer binding activity; and transcription coactivator activity. Involved in actin Cytoskeleton organization and positive regulation of transcription via serum response element binding activity. Acts upstream of or within negative regulation of apoptotic process; nervous system development; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in cerebellum; early conceptus; liver; oocyte; and telencephalon. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia and immunodeficiency 66. Orthologous to human MRTFA (myocardin related transcription factor A). [provided by Alliance of Genome Resources, Apr 2022]

Mrtfa Products (2)

mRNA Protein Name
NM_001082536.2 NP_001076005.2 myocardin-related transcription factor A isoform 2
NM_153049.3 NP_694629.2 myocardin-related transcription factor A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
17991879 MGI
enables actin binding IDA
IDA: Inferred from direct assay
15798203 MGI
enables actin monomer binding IDA
IDA: Inferred from direct assay
12732141 MGI
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
19008859 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12732141 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
17991879 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
12732141 MGI
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
24732378 MGI
acts upstream of or within actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
20534669 MGI
acts upstream of or within forebrain development IGI
IGI: Inferred from genetic interaction
20534669 MGI
acts upstream of or within negative regulation of apoptotic signaling pathway IDA
IDA: Inferred from direct assay
12019265 MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
12019265 MGI
acts upstream of or within neuron migration IGI
IGI: Inferred from genetic interaction
20534669 MGI
acts upstream of or within neuron projection development IGI
IGI: Inferred from genetic interaction
20534669 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12019265 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17991879 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12732141 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12732141 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12019265 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myocardin-related transcription factor A

  • MKL (megakaryoblastic leukemia)/myocardin-like 1

  • MKL/myocardin-like protein 1

  • basic SAP and coiled-coil domains

  • basic SAP coiled-coil transcription activator

  • megakaryoblastic leukemia (translocation) 1 homolog

  • megakaryocytic acute leukemia protein ho

Mrtfa Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Mrtfa Q8K4J6 KPNB1 Homo sapiens Q14974
Pull Down
20818336
Cross
Mrtfa Q8K4J6 ACTB Homo sapiens P60709
Pull Down
19008859
Cross
Mrtfa Q8K4J6 KPNA4 Homo sapiens O00629
Pull Down
20818336
Cross
Mrtfa Q8K4J6 ACTA1 Oryctolagus cuniculus P68135
X-Ray Diffraction
19008859
Cross
Mrtfa Q8K4J6 ACTA1 Oryctolagus cuniculus P68135
Fluorescence
19008859
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120855 CCG-100602 Inhibitor 99.29% Unkown
HY-13991A (S)-CCG-1423 / Unkown
HY-162968 MRTF-A-IN-1 Inhibitor / Unkown
HY-162969 MRTF-A-IN-2 Inhibitor / Unkown
HY-RS08693 MRTFA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21655 Mrtfa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28173 Mrtfa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mrtfa NCBI NCBI:57591