Kash5 - KASH domain containing 5 Gene

Also Known as Gm1434; Ccdc155

Species: Mus musculus

Gene Type: protein coding

Gene ID: 384619

Summary

Enables dynein complex binding activity and identical protein binding activity. Involved in Cytoskeleton organization; spindle localization; and telomere localization. Acts upstream of or within double-strand break repair via homologous recombination; gamete generation; and homologous chromosome segregation. Located in chromosome; meiotic spindle pole; and nuclear outer membrane. Part of meiotic nuclear membrane microtubule tethering complex. Is expressed in spermatocyte. Orthologous to human KASH5 (KASH domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]

Kash5 Products (1)

mRNA	Protein	Name
NM_201374.2	NP_958762.2	protein KASH5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dynein complex binding	IDA IDA: Inferred from direct assay	24062341	MGI
enables identical protein binding	IDA IDA: Inferred from direct assay	24062341	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22826121	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	26842404	MGI
acts upstream of or within chromosome localization to nuclear envelope involved in homologous chromosome segregation	IMP IMP: Inferred from mutant phenotype	24062341	MGI
acts upstream of or within double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	24062341	MGI
acts upstream of or within homologous chromosome pairing at meiosis	IMP IMP: Inferred from mutant phenotype	24062341	MGI
acts upstream of or within meiotic telomere clustering	IPI IPI: Inferred from physical interaction	24062341	MGI
acts upstream of or within oogenesis	IMP IMP: Inferred from mutant phenotype	24062341	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	24062341	MGI
involved in spindle assembly	IDA IDA: Inferred from direct assay	26842404	MGI
involved in spindle localization	IDA IDA: Inferred from direct assay	26842404	MGI
involved in telomere localization	IMP IMP: Inferred from mutant phenotype	25892231	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	22826121	MGI
located in lateral element	IDA IDA: Inferred from direct assay	24062341	MGI
part of meiotic nuclear membrane microtubule tethering complex	IDA IDA: Inferred from direct assay	24062341	MGI
located in meiotic spindle pole	IDA IDA: Inferred from direct assay	26842404	MGI
located in nuclear outer membrane	IDA IDA: Inferred from direct assay	24062341	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein KASH5	KASH domain-containing protein 5 coiled-coil domain containing 155 coiled-coil domain-containing protein 155

Kash5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Kash5	Q80VJ8	Sun1	Mus musculus	Q9D666	IF	22826121
Intra	Kash5	Q80VJ8	Sun1	Mus musculus	Q9D666	Anti Bait CoIP	22826121

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07072	KASH5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kash5	NCBI	NCBI:147872