IL31 - interleukin 31 Gene

Also Known as IL-31

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 386653

About IL31

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,172,029-122,174,221 (from NCBI)

This gene has 1 transcript (splice variant) and 69 orthologues. Low expression observed in reference dataset.

Summary

IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating Other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]

IL31 Products (1)

mRNA	Protein	Name
NM_001014336.2	NP_001014358.1	interleukin-31 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	21182835	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL31 Protein Structure

IL31

0
100
164 a.a.

Protein Preferred Names	Protein Names
interleukin-31

IL31 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL31	Q6EBC2	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL31 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7217	IL-31 Protein, Human	Q6EBC2 (S24-T164)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73209	IL-31 Protein, Human (HEK293, His)	Q6EBC2/NP_001014358.1 (S24-T164)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700123AF	Animal-Free IL-31 Protein, Human (His)	Q6EBC2 (S24-T164)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Allergic Contact Dermatitis	Dermatitis, Allergic Contact Contact Dermatitis, Allergic Dermatitis Allergic Contact Allergic Contact Eczema Acd - [Allergic Contact Dermatitis] Allergic Contact Dermatitis, Unspecified Cause Allergic Dermatitis Allergic Eczema Allergy Dermatitis Allergy Eczema Allergic Contact Eczema Due To Clothing Or Footwear Perfume Allergic Contact Dermatitis Allergic Contact Dermatitis Due To Cosmetics Allergic Contact Eczema Due To Cosmetics Or Fragrances Allergic Contact Eczema Due To Dental Materials Allergic Contact Eczema Due To Food Flavours Or Additives Allergic Contact Eczema Due To Hairdressing Products Allergic Contact Eczema Due To Metals Or Metal Salts Allergic Contact Eczema Due To Proteins Allergic Contact Eczema Due To Plastics Or Resin Systems Allergic Contact Eczema Due To Preservatives Or Biocides Allergic Contact Eczema Due To Rubber Chemicals Rubber Dermatitis Allergic Contact Eczema Due To Systemic Medicaments Allergic Contact Eczema Due To Topical Medicaments Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Contact Dermatitis	Contact Dermatitis/Eczema Contact Eczema Dermatitis Venenata Dermatitis, Venenata Dermatitis Contact Dermatitis, Contact
Primary Cutaneous Amyloidosis	Plca Primary Localized Cutaneous Amyloidosis Familial Primary Localized Cutaneous Amyloidosis Amyloidosis Ix Lichen Amyloidosis Familial Amyloidosis, Primary Cutaneous Pca Amyloidosis 9 Amyloidosis Familial Cutaneous Lichen Fplca Familial Lichen Amyloidosis
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Dermatitis Herpetiformis	Duhring'S Disease Duhring-Brocq Disease Dermatosis Herpetiformis Brocq-Duhring Disease Dh Duhring Brocq Disease Dh - [Dermatitis Herpetiformis]
Mastocytosis, Cutaneous	Urticaria Pigmentosa Cutaneous Mastocytosis Diffuse Cutaneous Mastocytosis Maculopapular Cutaneous Mastocytosis Mastocytosis, Diffuse Cutaneous MASTC Mastocytosis, Maculopapular Cutaneous Mastocytosis, Systemic, Somatic Mastocytoma Dcm Diffuse Cutaneous Maculopapulous Mastocytosis Up/Mpcm Cm Mastocytosis, Systemic MASTSYS Mast Cell Disease Mast-Cell Disease Mast Cell Leukemia Mastocytosis, Indolent Mastocytosis With Associated Hematologic Disorder Mast Cell Neoplasm Benign Mastocytoma
Neurodermatitis
Mite Infestation	Mite Infestations Acariasis Infestation By Mites Nos
Chronic Spontaneous Urticaria	Chronic Idiopathic Urticaria
Pemphigoid
Eczema Herpeticum	Herpes Simplex Dermatitis Herpes Simplex Eyelid Dermatitis Kaposi Varicelliform Eruption Herpes Simplex Dermatitis Of Eyelid Herpes Simplex Virus Dermatitis Herpes Simplex Virus Eyelid Dermatitis
Urticaria	Nettle Rash Hives Wheal Urticaria Nos
Scabies	Sarcoptic Itch Infestation By Sarcoptes Scabiei Infestation By Sarcoptes Scabiei Var Hominis Infestation By Sarcoptes Scabiei Var. Hominis
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Psoriasis
Irritant Dermatitis	Irritant Contact Dermatitis Primary Irritant Dermatitis Dermatitis, Irritant Contact Dermatitis, Irritant Irritant Contact Eczema Icd - [Irritant Contact Dermatitis] Irritant Contact Dermatitis, Unspecified Cause Non-Allergic Contact Dermatitis Irritant Contact Eczema Due To Wet Work Irritant Contact Dermatitis Due To Detergents Irritant Contact Eczema Due To Solvents Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants Irritant Contact Eczema Due To Cosmetics Or Emollients Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials Irritant Contact Eczema Due To Plants Or Other Vegetable Matter Irritant Contact Eczema Due To Foods Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids Irritant Contact Eczema Due To Saliva Irritant Contact Eczema Due To Incontinence Incontinence-Associated Dermatitis
Parasitic Ectoparasitic Infectious Disease	Ectoparasitic Infestations Ectoparasitism
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Chronic Inducible Urticaria
Occupational Dermatitis	Dermatitis, Occupational Occupational Allergic Contact Dermatitis Occupational Eczema
Chronic Urticaria	Urticaria Chronic Chronic Spontaneous Urticaria Chronic Ordinary Urticaria
Fox-Fordyce Disease	Fox Fordyce Disease Apocrine Miliaria Fox-Fordyce Syndrome Miliaria, Apocrine
Skin Atrophy	Atrophic Condition Of Skin Atrophoderma Atrophy - Skin
Luminal Breast Carcinoma B	Luminal B Breast Carcinoma
Nasopharyngitis	Chronic Nasopharyngitis Chronic Rhinopharyngitis
Nasal Cavity Disease	Disorder Of Nasal Cavity
Nose Disease	Nose Diseases Disorder Of The Nose Nasal Disorder Abnormality Of The Nose
Integumentary System Disease
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19522C	Seladelpar (lysine dihydrate)		99.51%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99162	Nemolizumab	Inhibitor	99.70%	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99519	Vixarelimab	Inhibitor	96.90%	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145551	Atinvicitinib	Inhibitor	98.62%	Unkown
HY-170415	EGR-1-IN-3	Inhibitor	99.13%	Unkown
HY-156959	Ovalicin	Inhibitor	/	Unkown
HY-RS06754	IL31 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06755	IL31RA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174609	Human IL31 mRNA		/	Unkown
HY-RS17747	Il31 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20557	Il31ra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24213	Il31 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27066	Il31ra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99301	Lokivetmab	Inhibitor	≥99.0%	Unkown
HY-P991280	BMS-981164	Inhibitor	95.36%	Unkown
HY-P99557	Tirnovetmab	Inhibitor	99.97%	Unkown
HY-P990713	Nolavetbart		96%	Unkown
HY-P992247	Anti-IL-31 Antibody		/	Unkown
HY-P99864	Dovanvetmab		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IL31	VGNC	VGNC:80444
Canis familiaris	IL31	VGNC	VGNC:41980
Macaca mulatta	IL31	VGNC	VGNC:108352
Mus musculus	IL31	MGD	MGI:1923649
Rattus norvegicus	IL31	RGD	RGD:1585183
Others	IL31	NCBI