ARMS2 - age-related maculopathy susceptibility 2 Gene

Also Known as ARMD8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 387715

About ARMS2

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:122,454,653-122,457,352 (from NCBI)

This gene has 1 transcript (splice variant), 9 orthologues and is associated with 2 phenotypes. Biased expression in testis (RPKM 1.0), placenta (RPKM 1.0) and 6 other tissues.

Summary

This gene encodes a small secreted protein specific to primates. This protein is a component of the choroidal extracellular matrix of the eye. Mutations in this gene are associated with age-related macular degeneration. [provided by RefSeq, Sep 2017]

ARMS2 Products (1)

mRNA Protein Name
NM_001099667.3 NP_001093137.1 age-related maculopathy susceptibility protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
19696174 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in retina homeostasis IMP
IMP: Inferred from mutant phenotype
18511946 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in mitochondrion IDA
IDA: Inferred from direct assay
18511946 GOA
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
18511946 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

age-related maculopathy susceptibility protein 2

ARMS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ARMS2 P0C7Q2 HMCN1 Homo sapiens Q96RW7
Pull Down
19696174
Intra
ARMS2 P0C7Q2 HMCN1 Homo sapiens Q96RW7
Anti Tag CoIP
19696174
Intra
ARMS2 P0C7Q2 CFP Homo sapiens P27918
ELISA
28086806
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Macular Degeneration, Age-Related, 8

  • Age Related Macular Degeneration 8

  • ARMD8

  • Macular Degeneration, Age-Related, Type 8
Retinal Drusen
Central Serous Chorioretinopathy

  • Central Serous Chorioretinopathy After Bone Marrow Transplantation

  • Central Serous Choroidopathy

  • Cscr

  • Central Serous Retinopathy

  • Central Serous Choroidoretinopathy
Choroiditis

  • Posterior Uveitis
Macular Degeneration, Age-Related, 1

  • Macular Degeneration

  • Age-Related Macular Degeneration

  • Macular Degeneration, Age-Related

  • Age Related Macular Degeneration

  • Age Related Macular Degeneration 1

  • ARMD1

  • Senile Macular Degeneration

  • Maculopathy, Age-Related, 1

  • Macular Degeneration, Age-Related, Reduced Risk Of

  • Age Related Maculopathy 1

  • Age Related Maculopathies

  • Age Related Maculopathy

  • Senile Macular Retinal Degeneration

  • Macular Degeneration Of Retina

  • Age-Related Maculopathy

  • Amd

  • Armd

  • Age-Related Maculopathy, Susceptibility To

  • Maculopathy Age-Related

  • Macular Degeneration, Age-Related, 1, Susceptibility To

  • Maculopathy, Age-Related

  • Macular Degeneration, Age-Related, Type 1

  • Macular Degeneration, Age-Related, 2
Kuhnt-Junius Degeneration

  • Neovascular Age-Related Macular Degeneration

  • Exudative Senile Macular Degeneration Of Retina

  • Senile Macular Degeneration, Wet

  • Wet Senile Macular Retinal Degeneration

  • Exudative Age-Related Macular Degeneration

  • Exudative Macular Degeneration
Histoplasmosis

  • Darling Disease

  • Reticuloendotheliosis, X-Linked

  • Infection By Histoplasma Capsulatum

  • Histoplasma Infection

  • Reticuloendothelial Cytomycosis

  • Cytomycosis

  • Darling Histoplasmosis

  • African Histoplasmosis

  • Histoplasmosis Duboisii
Basal Laminar Drusen

  • Drusen Of Bruch Membrane

  • Drusen, Cuticular

  • Drusen, Early Adult-Onset, Grouped

  • Cuticular Drusen

  • Early Adult-Onset Grouped Drusen

  • BLD

  • Drusen Cuticular

  • Drusen Early Adult-Onset Grouped
Eye Disease

  • Eye Diseases

  • Abnormality Of The Eye

  • Toxoplasma Oculopathy
Degeneration Of Macula And Posterior Pole

  • Degeneration Of Macula And Posterior Pole Of Retina

  • Degeneration Of Macula Or Posterior Pole

  • Macular Degeneration Nos

  • Degenerative Disorder Of Macula

  • Drusen Macular Degeneration

  • Posterior Pole Macular Degeneration Of Eye

  • Macular Eye Degeneration

  • Macular Degeneration Of Retina, Unspecified

  • Pseudohole Degeneration Of Macula Of Retina
Retinal Detachment

  • Retinal Detachments

  • Rhegmatogenous Retinal Detachment

  • Ruptured Retina With Detachment

  • Retinal Hole With Detachment
Sorsby Fundus Dystrophy

  • SFD

  • Fundus Dystrophy, Pseudoinflammatory, Of Sorsby

  • Sorsby'S Fundus Dystrophy

  • Macular Dystrophy, Hemorrhagic

  • Hemorrhagic Macular Dystrophy

  • Pseudoinflammatory Fundus Dystrophy Of Sorsby

  • Sorsby'S Pseudoinflammatory Macular Dystrophy

  • Sorsby Pseudoinflammatory Fundus Dystrophy

  • Dystrophy, Fundus, Sorsby
Eye Degenerative Disease
Angioid Streaks
Toxic Maculopathy

  • Toxic Maculopathy Of Retina
Degenerative Myopia

  • Pathological Myopia

  • Myopia, Degenerative

  • Degenerative Progressive High Myopia

  • Progressive High Myopia

  • Progressive High Myopia
Doyne Honeycomb Retinal Dystrophy

  • DHRD

  • Doyne Honeycomb Degeneration Of Retina

  • Dhd

  • Malattia Leventinese

  • Ml

  • Mlvt

  • Dystrophy, Retinal, Doyne Honeycomb
Ocular Hyperemia

  • Hyperemia Eye

  • Hyperemia Of Conjunctiva
Retinal Disease

  • Retinal Diseases

  • Retinal Disorder

  • Retinal Disorders
Complement Component 2 Deficiency

  • C2D

  • C2 Deficiency

  • Complement 2 Deficiency

  • Complement Component-2
Vitelliform Macular Dystrophy

  • Best Disease

  • Juvenile-Onset Vitelliform Macular Dystrophy

  • Macular Dystrophy, Vitelliform

  • Best Macular Dystrophy

  • Vitelliform Dystrophy
Lens Disease

  • Lens Diseases
Refractive Error

  • Refractive Errors
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Stargardt Disease

  • Stargardt Disease 1

  • Stargardt Macular Dystrophy

  • Stargardt Disease-1

  • Juvenile Onset Macular Degeneration

  • Stargardt Macular Degeneration

  • Juvenile Macular Degeneration

  • Macular Dystrophy With Flecks, Type 1

  • Stgd

  • Fundus Flavimaculatus

  • Stargardt 1

  • Stargardts Disease
Sensory System Disease
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-W1048510C 2-Arm PEG40000-mal 95.0% Unkown
HY-RS01010 ARMS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1048510A 2-Arm PEG10000-mal / Unkown
HY-W1048510B 2-Arm PEG20000-mal / Unkown
HY-W1048510D 2-Arm PEG5000-mal / Unkown