LGALS1 - galectin 1 Gene

Also Known as GBP; GAL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3956

About LGALS1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,675,636-37,679,802 (from NCBI)

This gene has 7 transcripts (splice variants), 331 orthologues and 16 paralogues. Broad expression in fat (RPKM 642.6), endometrium (RPKM 479.1) and 23 other tissues.

Summary

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

LGALS1 Products (1)

mRNA	Protein	Name
NM_002305.4	NP_002296.1	galectin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10369126	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	24752896	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell-cell adhesion	IDA IDA: Inferred from direct assay	18796645	GOA
involved in negative regulation of T-helper 17 cell lineage commitment	IDA IDA: Inferred from direct assay	24752896	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	12730878	GOA
NOT involved in positive regulation of dendritic cell differentiation	IDA IDA: Inferred from direct assay	16116184	GOA
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	12730878	GOA
involved in positive regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	21670307	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of galectin complex	IPI IPI: Inferred from physical interaction	15476813	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	28992109	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LGALS1 Protein Structure

Gal-bind_lectin

0
100
135 a.a.

Protein Preferred Names	Protein Names
galectin-1	14 kDa laminin-binding protein

LGALS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LGALS1	P09382	KDR	Homo sapiens	P35968	Anti Tag CoIP	24529377
Intra	LGALS1	P09382	KDR	Homo sapiens	P35968	Anti Bait CoIP	24529377
Intra	LGALS1	P09382	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	LGALS1	P09382	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	LGALS1	P09382	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	LGALS1	P09382	ALCAM	Homo sapiens	Q13740	Pull Down	24945728
Intra	LGALS1	P09382	ALCAM	Homo sapiens	Q13740	Anti Tag CoIP	33961781
Intra	LGALS1	P09382	APOE	Homo sapiens	P02649	Validated Y2H	32814053
Intra	LGALS1	P09382	APOE	Homo sapiens	P02649	Y2H Pooling	32814053
Intra	LGALS1	P09382	APOE	Homo sapiens	P02649	Y2H Array	32814053
Intra	LGALS1	P09382	ITGA3	Homo sapiens	P26006	Anti Tag CoIP	33961781
Intra	LGALS1	P09382	CD6	Homo sapiens	P30203	Pull Down	24945728
Intra	LGALS1	P09382	CD6	Homo sapiens	P30203	ELISA	24945728
Intra	LGALS1	P09382	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	LGALS1	P09382	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	LGALS1	P09382	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LGALS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70273	Galectin-1/LGALS1 Protein, Human (His)	P09382 (A2-D135)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73072	Galectin-1/LGALS1 Protein, Human	P09382/NP_002296.1 (A2-D135)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70273AF	Animal-Free Galectin-1/LGALS1 Protein, Human (His)	P09382 (A2-D135)	≥ 95%, as determined by reducing SDS-PAGE.

LGALS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80403	Galectin 1 Antibody (YA422)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
HY-P84028	Galectin 1 Antibody (YA3725)	IHC-P, FC, ELISA	Human
HY-P84028A	Galectin 1 Antibody (YA3725)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Hypopyon Ulcer
Ring Corneal Ulcer
Fucosidosis	Alpha-L-Fucosidase Deficiency Fucosidase Deficiency Disease A-Fucosidase Deficiency Alpha Fucosidase Deficiency Lysosomal Storage Disease Caused By Defective Alpha-L-Fucosidase With Accumulation Of Fucose In The Tissues Alpha-Fucosidase Deficiency Fucosidase Deficiency FUCA1D
Mycotic Corneal Ulcer
Trophoblastic Neoplasm	Trophoblastic Tumor Trophoblastic Neoplasms
Epithelioid Trophoblastic Tumor	Trophoblastic Tumor, Epithelioid
Macular Degeneration, Age-Related, 15	Age Related Macular Degeneration 15 ARMD15 Macular Degeneration, Age-Related, 15, Susceptibility To Macular Degeneration, Age-Related, Type 15
Cataract 10, Multiple Types	Cataract 10 Multiple Types CTRCT10 Cataract, Congenital Zonular, With Sutural Opacities Cczs Congenital Zonular Cataract With Sutural Opacities Cataract, Congenital, Zonular With Sutural Opacities Cataract, Type 10, Multiple Types
Placental Site Trophoblastic Tumor	Trophoblastic Tumor Placental Site Trophoblastic Tumor, Placental Site Placental Site Trophoblastic Tumour Placental-Site Gestational Trophoblastic Neoplasm Placenta Neoplasm Psst Deciduoma Placental Cancer Primary Malignant Neoplasm Of Placenta
Chronic Monocytic Leukemia	Leukemia, Myeloid Leukemia, Monocytic, Chronic
Blood Group, Globoside System	Globe Disease GLOB Blood Group System, Globoside
Endophthalmitis
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Scrapie
Gestational Choriocarcinoma	Gestational Chorionepithelioma Molar Pregnancy With Choriocarcinoma
Gestational Trophoblastic Neoplasm	Hydatidiform Mole Molar Pregnancy Gestational Trophoblastic Neoplasia Gestational Trophoblastic Tumor Gtn Gestational Trophoblastic Disease Gestational Trophoblastic Neoplasms Hydatidiform Mole, Recurrent, 1 Hydatidiform Mole Benign Trophoblastic Disease Trophoblastic Disease Nos Trophoblastic Disorder Vesicular Mole Nos Vesicular Mole Hydatidiform Mole Nos
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Placenta Disease	Placenta Diseases Placenta Disorder Pregnancy Complications Placenta Disorders
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07602	LGALS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-176259	F3-PEG8-RiboTAC		/	Unkown
HY-RS17042	Lgals1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23487	Lgals1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LGALS1	RGD	RGD:69355
Mus musculus	LGALS1	MGD	MGI:96777
Bos taurus	LGALS1	VGNC	VGNC:30850
Felis catus	LGALS1	VGNC	VGNC:68038
Others	LGALS1	NCBI