Flrt2 - fibronectin leucine rich transmembrane protein 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 399558

Summary

Enables chemorepellent activity and Fibroblast Growth Factor receptor binding activity. Involved in basement membrane organization; cell adhesion involved in heart morphogenesis; and Fibroblast Growth Factor receptor signaling pathway. Acts upstream of or within axon guidance; positive regulation of synapse assembly; and regulation of neuron migration. Located in cell-cell junction and extracellular space. Is integral component of plasma membrane. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system epithelium; branchial arch; central nervous system; embryo mesenchyme; and sensory organ. Orthologous to human FLRT2 (fibronectin leucine rich transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Flrt2 Products (1)

mRNA Protein Name
NM_201518.4 NP_958926.1 leucine-rich repeat transmembrane protein FLRT2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemorepellent activity IDA
IDA: Inferred from direct assay
21673655 MGI
enables fibroblast growth factor receptor binding IPI
IPI: Inferred from physical interaction
16872596 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21673655 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon guidance IGI
IGI: Inferred from genetic interaction
21673655 MGI
involved in basement membrane organization IMP
IMP: Inferred from mutant phenotype
21350012 MGI
involved in cell adhesion involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
21350012 MGI
involved in fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16872596 MGI
involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
21350012 MGI
acts upstream of or within positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
24613359 MGI
acts upstream of or within regulation of neuron migration IGI
IGI: Inferred from genetic interaction
21673655 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
16872596 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
21673655 MGI
colocalizes with focal adhesion IDA
IDA: Inferred from direct assay
16872596 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
34744626 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16872596 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
34744626 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
34744626 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich repeat transmembrane protein FLRT2

Recombinant Flrt2 Proteins

Cat. No. Product Name Accession Purity
HY-P76934 FLRT2 Protein, Mouse (HEK293, His) Q8BLU0 (C36-S539) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175352 Nurr1 agonist 14 99.42% Unkown
HY-RS04985 FLRT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20020 Flrt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26523 Flrt2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Flrt2 NCBI NCBI:23768