LPO - lactoperoxidase Gene

Homo sapiens

Also known as SPO

Gene ID: 4025 | Gene type: protein coding

About LPO

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,238,584-58,268,518 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 5 paralogues. Restricted expression toward salivary gland (RPKM 211.8).

Summary

This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature Enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this Enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

LPO Products(2)

mRNA	Protein	Name
NM_001160102.2	NP_001153574.1	lactoperoxidase isoform 3 preproprotein
NM_006151.3	NP_006142.1	lactoperoxidase isoform 1 preproprotein

LPO Protein Structure

An_peroxidase

0
200
400
600
712 a.a.

Protein Preferred Names

Protein Names

lactoperoxidase

salivary peroxidase

Related Diseases

Diseases

Alias

Gingivitis

Chronic Gingivitis

Acute Gingivitis

Aplasia Of Lacrimal And Salivary Glands

ALSG	Congenital Absence Of Lacrimal Puncta And Salivary Glands
Xerostomia	Absence Of Salivary Glands
Parotid Aplasia Or Hypoplasia	Congenital Absence Of Lacrimal Puncta Or Salivary Glands
Alsg - [Aplasia Of Lacrimal Or Salivary Glands]

Common Cold

Acute Coryza	Acute Nasopharyngitis
Acute Rhinitis	Acute Viral Rhinopharyngitis
Nasopharyngitis - Acute	Nasopharyngitis, Acute
Rhino-Sinusitis	Rhinosinusitis
Common Colds	Acute Infective Rhinitis
Cold	Coryza
Head Cold	Infective Nasopharyngitis
Rhinopharyngitis	Acute Nasal Catarrh
Infective Rhinitis	Acute Nasopharyngeal Catarrh
Infective Nasopharyngitis Nos	Nasopharyngitis Nos
Epipharyngitis	Mucositis Nos
Inflammatory Disease Of Mucous Membrane	Mucosal Inflammation

Mastitis

Breast Inflammation	Inflammatory Breast Disease
Inflammatory Disease Of Breast	Inflammation Of Non-Human Mammary Gland
Inflammatory Disorder Of Breast	Mastitis Nos
Acute Mastitis Nos	Acute Nonpuerperal Mastitis
Nonpuerperal Mastitis Nos	Subacute Mastitis Nos

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Developmental And Epileptic Encephalopathy 75

DEE75	Epileptic Encephalopathy, Early Infantile, 75
Eiee75	Developmental And Epileptic Encephalopathy, 75
Early Infantile Epileptic Encephalopathy 75

Gingival Disease

Gingival Diseases	Gum Disease
Gingival Disorder	Gingivitis And Periodontal Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141809	GPX4-IN-3		99.90%	Unkown
HY-100148	ICI 211965	Inhibitor	/	Unkown
HY-113455	9S-HODE	Inducer	/	Unkown
HY-161388	NSCLC-IN-1	Inducer	/	Unkown
HY-161460	Ferroptosis-IN-7	Inhibitor	/	Unkown
HY-RS07773	LPO Human Pre-designed siRNA Set A		/	Unkown
HY-101579	LY 178002		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LPO	VGNC	VGNC:74440
Rattus norvegicus	LPO	RGD	RGD:1310051
Bos taurus	LPO	VGNC	VGNC:30970
Felis catus	LPO	VGNC	VGNC:68083
Mus musculus	LPO	MGD	MGI:1923363
Canis familiaris	LPO	VGNC	VGNC:42755
Others	LPO	NCBI

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