LPO - lactoperoxidase Gene

Also Known as SPO

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4025

About LPO

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,238,584-58,268,518 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 5 paralogues. Restricted expression toward salivary gland (RPKM 211.8).

Summary

This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and Other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

LPO Products (2)

mRNA Protein Name
NM_001160102.2 NP_001153574.1 lactoperoxidase isoform 3 preproprotein
NM_006151.3 NP_006142.1 lactoperoxidase isoform 1 preproprotein

LPO Protein Structure

An_peroxidase

An_peroxidase: Animal haem peroxidase (138 - 684)

  • 0
  • 200
  • 400
  • 600
  • 712 a.a.
Protein Preferred Names Protein Names

lactoperoxidase

  • salivary peroxidase

Related Diseases

Diseases Alias
Gingivitis

  • Chronic Gingivitis

  • Acute Gingivitis
Aplasia Of Lacrimal And Salivary Glands

  • ALSG

  • Congenital Absence Of Lacrimal Puncta And Salivary Glands

  • Xerostomia

  • Absence Of Salivary Glands

  • Parotid Aplasia Or Hypoplasia

  • Congenital Absence Of Lacrimal Puncta Or Salivary Glands

  • Alsg - [Aplasia Of Lacrimal Or Salivary Glands]
Common Cold

  • Acute Coryza

  • Acute Nasopharyngitis

  • Acute Rhinitis

  • Acute Viral Rhinopharyngitis

  • Nasopharyngitis - Acute

  • Nasopharyngitis, Acute

  • Rhino-Sinusitis

  • Rhinosinusitis

  • Common Colds

  • Acute Infective Rhinitis

  • Cold

  • Coryza

  • Head Cold

  • Infective Nasopharyngitis

  • Rhinopharyngitis

  • Acute Nasal Catarrh

  • Infective Rhinitis

  • Acute Nasopharyngeal Catarrh

  • Infective Nasopharyngitis Nos

  • Nasopharyngitis Nos

  • Epipharyngitis

  • Mucositis Nos

  • Inflammatory Disease Of Mucous Membrane

  • Mucosal Inflammation
Mastitis

  • Breast Inflammation

  • Inflammatory Breast Disease

  • Inflammatory Disease Of Breast

  • Inflammation Of Non-Human Mammary Gland

  • Inflammatory Disorder Of Breast

  • Mastitis Nos

  • Acute Mastitis Nos

  • Acute Nonpuerperal Mastitis

  • Nonpuerperal Mastitis Nos

  • Subacute Mastitis Nos
Dental Caries

  • Dental Caries Extending Into Pulp

  • Dental Caries Of Smooth Surface

  • Dental Caries Pit And Fissure

  • Smooth Surface Dental Caries

  • Dental Decay

  • Carious Teeth

  • Dental Cavity

  • Saprodontia

  • Teeth Decayed

  • Tooth Caries

  • Tooth Decay
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Developmental And Epileptic Encephalopathy 75

  • DEE75

  • Epileptic Encephalopathy, Early Infantile, 75

  • Eiee75

  • Developmental And Epileptic Encephalopathy, 75

  • Early Infantile Epileptic Encephalopathy 75
Gingival Disease

  • Gingival Diseases

  • Gum Disease

  • Gingival Disorder

  • Gingivitis And Periodontal Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141809 GPX4-IN-3 99.83% Unkown
HY-P5381 gp91 ds-tat 99.00% Unkown
HY-156418 KY386 99.86% Unkown
HY-178364 GPX4-IN-19 99.45% Unkown
HY-161460 Ferroptosis-IN-7 Inhibitor 99.40% Unkown
HY-D2878 MitoPeDPP 92.2% Unkown
HY-100148 ICI 211965 Inhibitor / Unkown
HY-101579 LY 178002 99.60% Unkown
HY-113455S1 9(S)-HODE-13C18 Inducer / Unkown
HY-161388 NSCLC-IN-1 Inducer / Unkown
HY-161930 PROTAC GPX4 degrader-3 / Unkown
HY-175633 ML210-ansaFc 96.0% Unkown
HY-175698 Ferroptosis inducer-9 / Unkown
HY-177483 OART / Unkown
HY-182066 Photosensitizer-9 Activator / Unkown
HY-RS07773 LPO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17622 Lpo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24082 Lpo Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LPO VGNC VGNC:74440
Rattus norvegicus LPO RGD RGD:1310051
Bos taurus LPO VGNC VGNC:30970
Felis catus LPO VGNC VGNC:68083
Mus musculus LPO MGD MGI:1923363
Canis familiaris LPO VGNC VGNC:42755
Others LPO NCBI