1. Metabolic Enzyme/Protease
  2. 5-Lipoxygenase
  3. ICI 211965

ICI 211965 (Synonyms: ZM-211965)

Cat. No.: HY-100148
Handling Instructions

ICI 211965 is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor.

For research use only. We do not sell to patients.

ICI 211965 Chemical Structure

ICI 211965 Chemical Structure

CAS No. : 129424-08-4

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10 mg USD 2404 Get quote

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ICI 211965 is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor.

IC50 & Target


In Vitro

ICI 211965 is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor. ICI 211965 reduces the leakage of lactate dehydrogenase (LD) and lipid peroxidation at concentrations related to its antioxidative effect and not to its 5-1ipoxygenase-inhibiting effect[1].


Please store the product under the recommended conditions in the Certificate of Analysis.

Cell Assay

The myocytes are plated on 35 mm plastic culture dishes at a density of approximately 9×105 cells/mL (1.8×106 cells/dish). The cells are kept in culture for 6 d at 37°C and 5% CO2 under aerobic conditions in a carbon dioxide incubator. During this period the cells are beating spontaneously at an approximate frequency of 20 to 40 beats/min. Each culture dish contains 0.9+0.2 mg protein. The antioxidant ICI 211965 is added to the culture medium at a final concentration of 0.1% ethanol. Cell damage is determined by leakage of lactate dehydrogenase (LD) to the medium, and is analyzed after 0.5, 1.0, 2.0, 3.0, and 5.0 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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ICI 211965
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ICI 211965

Cat. No.: HY-100148