1. Metabolic Enzyme/Protease
  2. 5-Lipoxygenase

ICI 211965 (Synonyms: ZM-211965)

Cat. No.: HY-100148
Handling Instructions

ICI 211965 is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor.

For research use only. We do not sell to patients.

ICI 211965 Chemical Structure

ICI 211965 Chemical Structure

CAS No. : 129424-08-4

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


ICI 211965 is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor.

IC50 & Target


In Vitro

ICI 211965 is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor. ICI 211965 reduces the leakage of lactate dehydrogenase (LD) and lipid peroxidation at concentrations related to its antioxidative effect and not to its 5-1ipoxygenase-inhibiting effect[1].

Cell Assay

The myocytes are plated on 35 mm plastic culture dishes at a density of approximately 9×105 cells/mL (1.8×106 cells/dish). The cells are kept in culture for 6 d at 37°C and 5% CO2 under aerobic conditions in a carbon dioxide incubator. During this period the cells are beating spontaneously at an approximate frequency of 20 to 40 beats/min. Each culture dish contains 0.9+0.2 mg protein. The antioxidant ICI 211965 is added to the culture medium at a final concentration of 0.1% ethanol. Cell damage is determined by leakage of lactate dehydrogenase (LD) to the medium, and is analyzed after 0.5, 1.0, 2.0, 3.0, and 5.0 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Product Name:
ICI 211965
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ICI 211965

Cat. No.: HY-100148