Dnmt3b - DNA methyltransferase 3 beta Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 444985

Summary

Enables DNA binding activity; chromatin binding activity; and histone deacetylase binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to hyperoxia; and response to alkaloid. Located in cytoplasm and nucleus. Biomarker of anxiety disorder; congenital heart disease; hepatocellular carcinoma; and prostatitis. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune disease (multiple); carcinoma (multiple); immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA Methyltransferase 3 beta). [provided by Alliance of Genome Resources, Apr 2022]

Dnmt3b Products (1)

mRNA Protein Name
NM_001396349.1 NP_001383278.1 DNA (cytosine-5)-methyltransferase 3B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
23671328 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
23671328 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
23671328 RGD
involved in cellular response to hyperoxia IEP
IEP: Inferred from expression pattern
23039253 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
23201423 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
26509893 RGD
involved in response to caffeine IEP
IEP: Inferred from expression pattern
24717552 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
23688924 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
22334722 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
23529784 RGD
involved in response to ionizing radiation IEP
IEP: Inferred from expression pattern
17148264 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
23433207 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
23333085 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16632870 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA (cytosine-5)-methyltransferase 3B

  • DNA (cytosine-5-)-methyltransferase 3 beta

  • DNA methyltransferase 3B

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W286743 Nε-(Carboxymethyl)-L-lysine Activator 99.70% Phase 3

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13962 SGI-1027 99.79% Unkown
HY-101925 CM-272 / Unkown
HY-103397 Nanaomycin A Inhibitor 98.18% Unkown
HY-124131 DS-437 Inhibitor 99.22% Unkown
HY-111544 EML741 Inhibitor / Unkown
HY-181955 MS1129 / Unkown
HY-135146G GSK-3484862 (GMP) / Unkown
HY-13689G Go 6983 (GMP) / Unkown
HY-149389 PNMT-IN-1 Inhibitor / Unkown
HY-182009 DNMT-IN-6 / Unkown
HY-182956 DNMT1 Degrader-1 Degrader / Unkown
HY-RS03912 DNMT3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-103397R Nanaomycin A (Standard) Inhibitor / Unkown
HY-RS16772 Dnmt3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23212 Dnmt3b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnmt3b NCBI NCBI:1789