NEU2 - neuraminidase 2 Gene

Also Known as SIAL2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4759

About NEU2

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,032,672-233,035,057 (from NCBI)

This gene has 1 transcript (splice variant), 115 orthologues and 3 paralogues. Low expression observed in reference dataset.

Summary

This gene belongs to a family of glycohydrolytic Enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008]

NEU2 Products (1)

mRNA Protein Name
NM_005383.2 NP_005374.2 sialidase-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables exo-alpha-sialidase activity IDA
IDA: Inferred from direct assay
14613940 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in ganglioside catabolic process IDA
IDA: Inferred from direct assay
14613940 GOA
involved in glycoprotein catabolic process IDA
IDA: Inferred from direct assay
14613940 GOA
involved in oligosaccharide catabolic process IDA
IDA: Inferred from direct assay
14613940 GOA
Cellular Component GO Annotation Evidence References Source
part of catalytic complex IDA
IDA: Inferred from direct assay
26193330 GOA
located in cytosol IDA
IDA: Inferred from direct assay
10561456 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEU2 Protein Structure

BNR_2

BNR_2: BNR repeat-like domain (33 - 342)

  • 0
  • 100
  • 200
  • 300
  • 380 a.a.
Protein Preferred Names Protein Names

sialidase-2

  • N-acetyl-alpha-neuraminidase 2

NEU2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NEU2 Q9Y3R4 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
NEU2 Q9Y3R4 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
NEU2 Q9Y3R4 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25910212
Intra
NEU2 Q9Y3R4 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25910212
Intra
NEU2 Q9Y3R4 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Bait-Prey Pool
25910212
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NEU2 Proteins

Cat. No. Product Name Accession Purity
HY-P74733 NEU2 Protein, Human (HEK293, His) Q9Y3R4 (M1-Q380) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Glycoproteinosis

  • Sialidosis

  • Mucolipidosis Type I

  • Mucolipidoses

  • Cherry Red Spot Myoclonus Syndrome

  • Mucolipidosis I

  • Myoclonus Cherry Red Spot Syndrome

  • Type I Mucolipidosis

  • Lipomucopolysaccharidosis

  • Disorders Of Glycoprotein Metabolism

  • Glycoprotein Storage Disorder
Galactosialidosis

  • Goldberg Syndrome

  • Neuraminidase Deficiency With Beta-Galactosidase Deficiency

  • Ppca Deficiency

  • GSL

  • Lysosomal Protective Protein Deficiency

  • Cathepsin A Deficiency

  • Neuraminidase/Beta-Galactosidase Expression

  • Protective Protein/Cathepsin A Deficiency

  • Ngbe

  • Cathepsin A Deficiency Of

  • Lysosomal Protective Protein Deficiency Of

  • Deficiency Of Cathepsin A

  • Neuraminidase Beta-Galactosidase Deficiency

  • Protective Protein Cathepsin A Deficiency
Breast Medullary Carcinoma

  • Medullary Breast Carcinoma

  • Medullary Breast Carcinoma With Lymphoid Stroma

  • Medullary Carcinoma Of Breast
Mucolipidosis
Breast Rhabdomyosarcoma

  • Rhabdomyosarcoma Of The Breast
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus NEU2 MGD MGI:1344417
Felis catus NEU2 VGNC VGNC:80291
Bos taurus NEU2 VGNC VGNC:50231
Canis familiaris NEU2 VGNC VGNC:54976
Macaca mulatta NEU2 VGNC VGNC:75317
Rattus norvegicus NEU2 RGD RGD:3164
Others NEU2 NCBI