SYK - spleen associated tyrosine kinase Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 484196

About SYK

Primary_assembly 1: 96,506,228-96,590,524 reverse strand.ROS_Cfam_1.0:CM025100.1

This gene has 4 transcripts (splice variants), 202 orthologues and 32 paralogues.

SYK Products (4)

mRNA Protein Name
XM_038655412.1 XP_038511340.1 tyrosine-protein kinase SYK isoform X2
XM_038655409.1 XP_038511337.1 tyrosine-protein kinase SYK isoform X1
XM_038655411.1 XP_038511339.1 tyrosine-protein kinase SYK isoform X1
XM_038655410.1 XP_038511338.1 tyrosine-protein kinase SYK isoform X1

SYK Protein Structure

SH2_N-SH2_Zap70_Syk_like

SH2_N-SH2_Zap70_Syk_like: cd09938 (11 - 114)

SH2_C-SH2_Syk_like

SH2_C-SH2_Syk_like: cd10401 (162 - 260)

PTKc_Syk

PTKc_Syk: cd05116 (373 - 628)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 633 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase SYK

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13038A Fostamatinib Inhibitor 99.70% Yes
HY-13038 Fostamatinib Disodium Inhibitor 98.94% Yes
HY-13038B Fostamatinib disodium hexahydrate Inhibitor 99.46% Yes

Clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Phase
HY-15968 Entospletinib Inhibitor 99.49% Phase 3
HY-15999 Cerdulatinib Inhibitor 99.06% Phase 3
HY-15999A Cerdulatinib hydrochloride Inhibitor 98.96% Phase 3
HY-15322 PRT062607 Inhibitor 99.38% Phase 2
HY-15323 PRT062607 Hydrochloride Inhibitor 98.07% Phase 2
HY-103018 Gusacitinib Inhibitor 99.63% Phase 2
HY-109091 Lanraplenib Inhibitor 99.13% Phase 2
HY-109082 Cevidoplenib Inhibitor 99.58% Phase 2
HY-109091B Lanraplenib succinate Inhibitor 98.09% Phase 2
HY-112319 (R,S)-MK-8457 / Phase 2
HY-100867 Mivavotinib Inhibitor / Phase 2
HY-109091A Lanraplenib monosuccinate Inhibitor / Phase 2
HY-103018A Gusacitinib hydrochloride Inhibitor / Phase 2
HY-13518 Piceatannol Inhibitor 98.97% Phase 1
HY-112809 GSK2646264 Inhibitor 99.74% Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P991734 VHB937 Activator 99.9% Phase 2
HY-P991954 GT103 / Phase 2

Pre-clinical Phase

Bioactive Molecules (67)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12067 R406 Inhibitor 97.91% Unkown
HY-14985 BAY 61-3606 dihydrochloride Inhibitor 99.45% Unkown
HY-11108 R406 free base Inhibitor 99.07% Unkown
HY-100867A Mivavotinib monohydrochloride Inhibitor 99.91% Unkown
HY-N0805 Alisol B 23-acetate Inhibitor 99.65% Unkown
HY-12974 PRT-060318 Inhibitor 99.59% Unkown
HY-145598 Sovleplenib Inhibitor 99.94% Unkown
HY-N7675 Flavanomarein Inhibitor 99.92% Unkown
HY-112390A Syk Inhibitor II Inhibitor 98.15% Unkown
HY-78263 MNS Inhibitor 99.55% Unkown
HY-76474A BAY 61-3606 hydrochloride Inhibitor 98.08% Unkown
HY-174369 TREM2 agonist-3 Activator 99.39% Unkown
HY-12736A GSK143 dihydrochloride Inhibitor 99.37% Unkown
HY-131341 Syk-IN-4 Inhibitor 98.0% Unkown
HY-16420 R112 Inhibitor 98.90% Unkown
HY-136198 SRX3207 Inhibitor 98.50% Unkown
HY-P6442 Chemerin15 Inhibitor 99.65% Unkown
HY-16902 RO9021 Inhibitor 98.88% Unkown
HY-112386 OXSI-2 Inhibitor 99.9% Unkown
HY-15324 PRT062607 acetate Inhibitor 99.83% Unkown
HY-15324 PRT062607 acetate Inhibitor 99.83% Unkown
HY-160142 UBX-382 Inhibitor 96.20% Unkown
HY-109082A Cevidoplenib dimesylate Inhibitor 98.96% Unkown
HY-18623 VI 16832 Ligand 99.09% Unkown
HY-182702 As48 Activator / Unkown
HY-178129 MRL-SYKi Inhibitor 98.97% Unkown
HY-178324 T2M-010 Activator / Unkown
HY-108489 ER-27319 maleate Inhibitor 99.4% Unkown
HY-156872 MTX-216 Inhibitor / Unkown
HY-10230S Midostaurin-d5 Inhibitor 98.0% Unkown
HY-138961 ER-27319 Inhibitor 98.66% Unkown
HY-12974A PRT-060318 dihydrochloride Inhibitor 98.98% Unkown
HY-12657 Syk-IN-1 Inhibitor 99.18% Unkown
HY-112390 Syk Inhibitor II dihydrochloride Inhibitor / Unkown
HY-76474 BAY 61-3606 Inhibitor 98.21% Unkown
HY-124146 BI1002494 Inhibitor / Unkown
HY-184063 Vexicitinib Inhibitor / Unkown
HY-112390B Syk Inhibitor II dihydrochloride dihydrate Inhibitor / Unkown
HY-15322A (rel)-PRT062607 Inhibitor / Unkown
HY-162427 NMS-0963 Inhibitor / Unkown
HY-125500 TOP1362 Inhibitor / Unkown
HY-112390C Syk Inhibitor II hydrochloride Inhibitor / Unkown
HY-184306 SYK-IN-15 Inhibitor / Unkown
HY-112319A MK-8457 Inhibitor / Unkown
HY-103018S Gusacitinib-d4 / Unkown
HY-156196 BI 894416 Inhibitor / Unkown
HY-125585 Syk-IN-2 Inhibitor / Unkown
HY-169630 DBMB Inhibitor / Unkown
HY-184415 Syk/HDAC6-IN-1 Inhibitor / Unkown
HY-149895 Syk-IN-7 Inhibitor / Unkown
HY-P2504 Syk Kinase Peptide Substrate, Biotin labeled / Unkown
HY-155513 Syk-IN-8 Inhibitor / Unkown
HY-145029 SYK/JAK-IN-1 Inhibitor / Unkown
HY-P2505 Syk Kinase Peptide Substrate / Unkown
HY-120214 TAS05567 Inhibitor / Unkown
HY-184655 Syk-IN-16 Inhibitor / Unkown
HY-124605 IQS-019 Inhibitor / Unkown
HY-181546 Ibt-DOX Control / Unkown
HY-12736 GSK143 Inhibitor / Unkown
HY-120533 Syk-IN-11 Inhibitor / Unkown
HY-18911 Type-II-IN-1 Inhibitor / Unkown
HY-N7314 Asebogenin Inhibitor / Unkown
HY-183924 SYK-IN-14 Inhibitor / Unkown
HY-174284 Syk-IN-13 Inhibitor / Unkown
HY-123625 R-348 choline Inhibitor / Unkown
HY-160930 TOP1288 Inhibitor / Unkown
HY-N3702 Dehydroabietinol Inhibitor 98.90% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SYK NCBI NCBI:6850