ENG - Eng endoglin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 497010

Summary

Enables type II transforming growth factor beta receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of Collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Used to study congestive heart failure; pre-eclampsia; and renal fibrosis. Biomarker of cholestasis; congestive heart failure; hepatocellular carcinoma; hypertension (multiple); and renal fibrosis. Human ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin). [provided by Alliance of Genome Resources, Apr 2022]

ENG Products (1)

mRNA Protein Name
NM_001010968.3 NP_001010968.1 endoglin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables type II transforming growth factor beta receptor binding IPI
IPI: Inferred from physical interaction
21146604 RGD
Biological Process GO Annotation Evidence References Source
involved in bone development IEP
IEP: Inferred from expression pattern
20865666 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
22941949 RGD
involved in extracellular matrix constituent secretion IMP
IMP: Inferred from mutant phenotype
15539634 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
20156938 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21146604 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
21146604 RGD
involved in regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
17376778 RGD
involved in response to transforming growth factor beta IEP
IEP: Inferred from expression pattern
22941949 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
20156938 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15537649 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
19075097 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endoglin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-186189 OPA-S-S-alkyne / Unkown
HY-RS04374 ENG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W782599 Senkyunolide B Inhibitor / Unkown
HY-RS17441 Eng Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23897 Eng Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ENG NCBI NCBI:2022