HSD17B14 - hydroxysteroid 17-beta dehydrogenase 14 Gene

Also Known as DHRS10; SDR47C1; retSDR3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51171

About HSD17B14

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,813,018-48,836,491 (from NCBI)

This gene has 4 transcripts (splice variants), 159 orthologues and 25 paralogues. Broad expression in kidney (RPKM 32.8), ovary (RPKM 12.9) and 14 other tissues.

Summary

17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of Steroids at the C17 position and also of other substrates, such as Fatty Acids, Prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]

HSD17B14 Products (1)

mRNA Protein Name
NM_016246.3 NP_057330.2 17-beta-hydroxysteroid dehydrogenase 14

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
17067289 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables testosterone 17-beta-dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
17067289 GOA
Biological Process GO Annotation Evidence References Source
involved in steroid catabolic process IDA
IDA: Inferred from direct assay
17067289 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
17067289 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSD17B14 Protein Structure

adh_short

adh_short: short chain dehydrogenase (10 - 170)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

17-beta-hydroxysteroid dehydrogenase 14

  • 17-beta-HSD 14

HSD17B14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HSD17B14 Q9BPX1 DDIT3 Homo sapiens P35638-2
Validated Y2H
25416956
Intra
HSD17B14 Q9BPX1 tmp_locus_54 Homo sapiens Q53NU3
Y2H Prey Pooling
25416956
Intra
HSD17B14 Q9BPX1 tmp_locus_54 Homo sapiens Q53NU3
Y2H Array
25416956
Intra
HSD17B14 Q9BPX1 MGC4677 Homo sapiens Q53S70
Validated Y2H
25416956
Intra
HSD17B14 Q9BPX1 SNRPC Homo sapiens Q5TAL4
Validated Y2H
25416956
Intra
HSD17B14 Q9BPX1 SNRPC Homo sapiens Q5TAL4
Y2H Array
25416956
Intra
HSD17B14 Q9BPX1 SREK1IP1 Homo sapiens Q8N9Q2
Validated Y2H
25416956
Intra
HSD17B14 Q9BPX1 SREK1IP1 Homo sapiens Q8N9Q2
Y2H Prey Pooling
25416956
Intra
HSD17B14 Q9BPX1 SREK1IP1 Homo sapiens Q8N9Q2
Y2H Array
25416956
Intra
HSD17B14 Q9BPX1 MPG Homo sapiens P29372
Y2H Array
25416956
Intra
HSD17B14 Q9BPX1 MPG Homo sapiens P29372
Y2H Array
31515488
Intra
HSD17B14 Q9BPX1 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
HSD17B14 Q9BPX1 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
HSD17B14 Q9BPX1 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
Intra
HSD17B14 Q9BPX1 PIDD1 Homo sapiens Q9HB75-2
Validated Y2H
32296183
Intra
HSD17B14 Q9BPX1 OTUD3 Homo sapiens Q5T2D3
Y2H Array
32296183
Intra
HSD17B14 Q9BPX1 OTUD3 Homo sapiens Q5T2D3
Y2H Prey Pooling
32296183
Intra
HSD17B14 Q9BPX1 SNAPC3 Homo sapiens Q92966
Validated Y2H
25416956
Intra
HSD17B14 Q9BPX1 SNAPC3 Homo sapiens Q92966
Y2H Prey Pooling
25416956
Intra
HSD17B14 Q9BPX1 BRIP1 Homo sapiens Q9BX63
Anti Tag CoIP
33961781
Intra
HSD17B14 Q9BPX1 BRIP1 Homo sapiens Q9BX63
Validated Y2H
32296183
Intra
HSD17B14 Q9BPX1 PHF1 Homo sapiens O43189
Y2H Array
31515488
Intra
HSD17B14 Q9BPX1 PHF1 Homo sapiens O43189
Y2H Prey Pooling
25416956
Intra
HSD17B14 Q9BPX1 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
HSD17B14 Q9BPX1 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
HSD17B14 Q9BPX1 CA8 Homo sapiens P35219
Y2H Prey Pooling
25416956
Intra
HSD17B14 Q9BPX1 CA8 Homo sapiens P35219
Y2H Array
25416956
Intra
HSD17B14 Q9BPX1 CA8 Homo sapiens P35219
Validated Y2H
27107012
Intra
HSD17B14 Q9BPX1 NEK6 Homo sapiens Q9HC98
Validated Y2H
25416956
Intra
HSD17B14 Q9BPX1 NUDT18 Homo sapiens Q6ZVK8
Y2H Pooling
16189514
Intra
HSD17B14 Q9BPX1 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
27107012
Intra
HSD17B14 Q9BPX1 NTAQ1 Homo sapiens Q96HA8
Y2H Pooling
19060904
Intra
HSD17B14 Q9BPX1 NTAQ1 Homo sapiens Q96HA8
Y2H Array
19060904
Intra
HSD17B14 Q9BPX1 NTAQ1 Homo sapiens Q96HA8
Y2H Array
31515488
Intra
HSD17B14 Q9BPX1 NTAQ1 Homo sapiens Q96HA8
Y2H Pooling
16189514
Intra
HSD17B14 Q9BPX1 DDIT3 Homo sapiens P35638
BFG-2H
27107012
Intra
HSD17B14 Q9BPX1 DDIT3 Homo sapiens P35638
Y2H Array
32296183
Intra
HSD17B14 Q9BPX1 DDIT3 Homo sapiens P35638
Y2H Prey Pooling
32296183
Intra
HSD17B14 Q9BPX1 CDKN2D Homo sapiens P55273
Validated Y2H
25416956
Intra
HSD17B14 Q9BPX1 CDKN2D Homo sapiens P55273
Y2H Array
25416956
Intra
HSD17B14 Q9BPX1 CDKN2D Homo sapiens P55273
Y2H Prey Pooling
25416956
Intra
HSD17B14 Q9BPX1 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
HSD17B14 Q9BPX1 TBC1D22B Homo sapiens Q9NU19
Y2H Array
29892012
Intra
HSD17B14 Q9BPX1 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
32296183
Intra
HSD17B14 Q9BPX1 TBC1D22B Homo sapiens Q9NU19
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HSD17B14 Proteins

Cat. No. Product Name Accession Purity
HY-P76975 HSD17B14 Protein, Human (HEK293, His) Q9BPX1/NP_057330.2 (M1-S270) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06394 HSD17B14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22064 Hsd17b14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28582 Hsd17b14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HSD17B14 RGD RGD:1588673
Mus musculus HSD17B14 MGD MGI:1913315
Bos taurus HSD17B14 VGNC VGNC:29972
Felis catus HSD17B14 VGNC VGNC:97458
Canis familiaris HSD17B14 VGNC VGNC:41804
Others HSD17B14 NCBI