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ATP5F1D - ATP synthase F1 subunit delta Gene

Also Known as ATP5D; MC5DN5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 513

About ATP5F1D

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,241,751-1,244,825 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 30.9), colon (RPKM 30.8) and 25 other tissues.

Summary

This gene encodes a subunit of mitochondrial ATP Synthase. Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during Oxidative Phosphorylation. ATP Synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP Synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the Other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

ATP5F1D Products (2)

mRNA	Protein	Name
NM_001001975.2	NP_001001975.1	ATP synthase subunit delta, mitochondrial precursor
NM_001687.5	NP_001678.1	ATP synthase subunit delta, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
contributes to proton-transporting ATP synthase activity, rotational mechanism	IDA IDA: Inferred from direct assay	12110673	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in aerobic respiration	IMP IMP: Inferred from mutant phenotype	29478781	GOA
involved in mitochondrial proton-transporting ATP synthase complex assembly	IMP IMP: Inferred from mutant phenotype	29478781	GOA
involved in proton motive force-driven mitochondrial ATP synthesis	IDA IDA: Inferred from direct assay	12110673	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of proton-transporting ATP synthase complex	IDA IDA: Inferred from direct assay	12110673	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP5F1D Protein Structure

ATP-synt_DE_N

0
100
168 a.a.

Protein Preferred Names	Protein Names
ATP synthase subunit delta, mitochondrial	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit

ATP5F1D Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATP5F1D	P30049	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	ATP5F1D	P30049	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	ATP5F1D	P30049	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	ATP5F1D	P30049	SRSF11	Homo sapiens	Q05519-2	Validated Y2H	32296183
Intra	ATP5F1D	P30049	SRSF11	Homo sapiens	Q05519-2	Y2H Array	32296183
Intra	ATP5F1D	P30049	SRSF11	Homo sapiens	Q05519-2	Y2H Prey Pooling	32296183
Intra	ATP5F1D	P30049	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	ATP5F1D	P30049	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	ATP5F1D	P30049	ATP5F1E	Homo sapiens	P56381	Anti Tag CoIP	33961781
Intra	ATP5F1D	P30049	ATP5F1E	Homo sapiens	P56381	Anti Tag CoIP	28514442
Intra	ATP5F1D	P30049	ATP5F1E	Homo sapiens	P56381	Validated Y2H	32296183
Intra	ATP5F1D	P30049	ATP5F1E	Homo sapiens	P56381	Y2H Prey Pooling	32296183
Intra	ATP5F1D	P30049	ATP5F1E	Homo sapiens	P56381	Y2H Array	32296183
Intra	ATP5F1D	P30049	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	ATP5F1D	P30049	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	ATP5F1D	P30049	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	ATP5F1D	P30049	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	ATP5F1D	P30049	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	ATP5F1D	P30049	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	ATP5F1D	P30049	TNS2	Homo sapiens	Q63HR2	Y2H Array	32296183
Intra	ATP5F1D	P30049	TNS2	Homo sapiens	Q63HR2	Y2H Prey Pooling	32296183
Intra	ATP5F1D	P30049	TNS2	Homo sapiens	Q63HR2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATP5F1D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72097	ATP5D Protein, Human (His-SUMO)	P30049 (A23-E168)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72098	ATP5D Protein, Human (His)	P30049 (A23-E168)	≥ 90%, as determined by reducing SDS-PAGE.

ATP5F1D Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811172	ATP5D Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Mitochondrial Complex V Deficiency, Nuclear Type 5	Mitochondrial Complex V Deficiency MC5DN5 Mitochondrial Complex V Deficiency, Atp5f1d Type Mitochondrial Complex V Deficiency Mitochondrial Complex 5 Deficiency Nuclear Type 5 Complex 5 Mitochondrial Respiratory Chain Deficiency Atp Synthase Deficiency Mitochondrial Complex V Deficiency, Nuclear Type 5 Complex V Deficiency
Isolated Atp Synthase Deficiency	Isolated Mitochondrial Respiratory Chain Complex V Deficiency
Mitochondrial Disease	Mitochondrial Diseases Mitochondrial Disorder
3-Methylglutaconic Aciduria	3-Methyl Glutaconic Aciduria
Ciliary Dyskinesia, Primary, 30	Primary Ciliary Dyskinesia 30 CILD30 Ciliary Dyskinesia, Primary, 30, With Or Without Situs Inversus Primary Ciliary Dyskinesia 30 Without Situs Inversus Primary Ciliary Dyskinesia 30 With Or Without Situs Inversus Dyskinesia, Ciliary, Primary, Type 30
Lactic Acidosis	Acidosis, Lactic Acidosis Lactic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01205	ATP5F1D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21988	Atp5f1d Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28506	Atp5f1d Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATP5F1D	VGNC	VGNC:102003
Rattus norvegicus	ATP5F1D	RGD	RGD:621372
Macaca mulatta	ATP5F1D	VGNC	VGNC:108475
Canis familiaris	ATP5F1D	VGNC	VGNC:38264
Mus musculus	ATP5F1D	MGD	MGI:1913293
Bos taurus	ATP5F1D	VGNC	VGNC:26302
Others	ATP5F1D	NCBI