TRIAP1 - TP53 regulated inhibitor of apoptosis 1 Gene

Also Known as WF-1; MDM35; P53CSV; HSPC132

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51499

About TRIAP1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,443,964-120,446,384 (from NCBI)

This gene has 2 transcripts (splice variants) and 101 orthologues. Ubiquitous expression in colon (RPKM 17.2), liver (RPKM 15.9) and 25 other tissues.

Summary

Enables p53 binding activity. Contributes to phosphatidic acid transfer activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of apoptotic process; and positive regulation of phospholipid transport. Located in mitochondrial intermembrane space and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

TRIAP1 Products (1)

mRNA	Protein	Name
NM_016399.3	NP_057483.1	TP53-regulated inhibitor of apoptosis 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables p53 binding	IPI IPI: Inferred from physical interaction	15735003	GOA
contributes to phosphatidic acid transfer activity	IDA IDA: Inferred from direct assay	23931759	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15735003	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	15735003	GOA
involved in cellular response to UV	IDA IDA: Inferred from direct assay	15735003	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	23931759	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	15735003	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	15735003	GOA
involved in negative regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	23931759	GOA
involved in phospholipid transport	IDA IDA: Inferred from direct assay	26071602	GOA
involved in positive regulation of phospholipid transport	IDA IDA: Inferred from direct assay	23931759	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15735003	GOA
involved in regulation of membrane lipid distribution	IMP IMP: Inferred from mutant phenotype	23931759	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	23931759	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	15735003	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23931759	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIAP1 Protein Structure

UPF0203

0
76 a.a.

Protein Preferred Names	Protein Names
TP53-regulated inhibitor of apoptosis 1	mitochondrial distribution and morphology 35 homolog

TRIAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIAP1	O43715	LCN2	Homo sapiens	P80188	Validated Y2H	32296183
Intra	TRIAP1	O43715	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	TRIAP1	O43715	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	TRIAP1	O43715	PRELID3B	Homo sapiens	Q9Y3B1	Anti Tag CoIP	33961781
Intra	TRIAP1	O43715	PRELID3B	Homo sapiens	Q9Y3B1	Anti Tag CoIP	28514442
Intra	TRIAP1	O43715	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	TRIAP1	O43715	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	TRIAP1	O43715	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Penile Cancer	Penis Carcinoma Carcinoma Of Penis Penile Neoplasm Penile Carcinoma Penile Neoplasms Malignant Neoplasm Of Penis Ca Penis Malignant Neoplasm Of Body Of Penis Malignant Penile Tumor Penile Ca
Immune-Complex Glomerulonephritis	Immune Complex Glomerulonephritis
Waardenburg Syndrome, Type 1	Waardenburg Syndrome Type 1 WS1 Waardenburg Syndrome Type I Waardenburg Syndrome With Dystopia Canthorum Waardenburg'S Syndrome Type 1 Waardenburg Syndrome 1 Waardenburg Syndrome, Type I Waardenburg Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15014	TRIAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRIAP1	VGNC	VGNC:36307
Canis familiaris	TRIAP1	VGNC	VGNC:47800
Rattus norvegicus	TRIAP1	RGD	RGD:1586233
Mus musculus	TRIAP1	MGD	MGI:1916326